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The sodium bile salt cotransport family SLC10

Hagenbuch, Bruno ; Dawson, Paul

In: Pflügers Archiv, 2004, vol. 447, no. 5, p. 566-570

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    Titre
    • The sodium bile salt cotransport family SLC10
    Auteur
    • Hagenbuch, Bruno. Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    • Dawson, Paul. Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317561
    Summary
    The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT)