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Preliminary results on the postmortem measurement of 3-beta-hydroxybutyrate in liver homogenates

Palmiere, Cristian ; Mangin, Patrice ; Werner, Dominique

In: International Journal of Legal Medicine, 2013, vol. 127, no. 5, p. 943-949

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    Titre
    • Preliminary results on the postmortem measurement of 3-beta-hydroxybutyrate in liver homogenates
    Auteur
    • Palmiere, Cristian. University Center of Legal Medicine, University of Lausanne, Rue du Bugnon 21, 1011, Lausanne, Switzerland
    • Mangin, Patrice. University Center of Legal Medicine, University of Lausanne, Rue du Bugnon 21, 1011, Lausanne, Switzerland
    • Werner, Dominique. Laboratory of Clinical Chemistry, Lausanne University Hospital, 1011, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • International Journal of Legal Medicine, 2013, vol. 127, no. 5, p. 943-949. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317446
    Summary
    The concentrations of 3-beta-hydroxybutyrate (3HB) in blood and two liver samples were retrospectively examined in a series of medicolegal autopsies. These cases included diabetic ketoacidosis, nondiabetic individuals presenting moderate to severe decompositional changes and nondiabetic medicolegal cases privy of decompositional changes. 3HB concentrations in liver sample homogenates correlate well with blood values in all examined groups. Additionally, decompositional changes were not associated with increases in blood and liver 3HB levels. These results suggest that 3HB can be reliably measured in liver homogenates when blood is not available at autopsy. Furthermore, they suggest that metabolic disturbances potentially leading or contributing to death may be objectified through liver 3HB determination even in decomposed bodies