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Clinical Implications of Molecular Neuropathology and Biomarkers for Malignant Glioma

Tabatabai, Ghazaleh ; Hegi, Monika ; Stupp, Roger ; Weller, Michael

In: Current Neurology and Neuroscience Reports, 2012, vol. 12, no. 3, p. 302-307

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    Titel
    • Clinical Implications of Molecular Neuropathology and Biomarkers for Malignant Glioma
    Autor
    • Tabatabai, Ghazaleh. Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland
    • Hegi, Monika. Department of Neurosurgery and Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    • Stupp, Roger. Department of Neurosurgery and Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    • Weller, Michael. Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Current Neurology and Neuroscience Reports, 2012, vol. 12, no. 3, p. 302-307. Current Science Inc.
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:317201
    Summary
    Malignant gliomas are currently diagnosed based on morphological criteria and graded according to the World Health Organization classification of primary brain tumors. This algorithm of diagnosis and classification provides clinicians with an estimated prognosis of the natural course of the disease. It does not reflect the expected response to specific treatments beyond surgery (eg, radiotherapy or alkylating chemotherapy). Clinical experience has revealed that gliomas sharing similar histomorphological criteria might indeed have different clinical courses and exhibit highly heterogenous responses to treatments. This was very impressively demonstrated first for oligodendrogliomas. The presence or lack of combined deletions of the chromosomal segments 1p/19q was associated with different benefit from radiotherapy and chemotherapy. We review current molecular markers for malignant gliomas and discuss their current and future impact on clinical neuro-oncology