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Model-based iterative reconstruction in pediatric chest CT: assessment of image quality in a prospective study of children with cystic fibrosis

Miéville, Frédéric ; Berteloot, Laureline ; Grandjean, Albane ; Ayestaran, Paul ; Gudinchet, François ; Schmidt, Sabine ; Brunelle, Francis ; Bochud, François ; Verdun, Francis

In: Pediatric Radiology, 2013, vol. 43, no. 5, p. 558-567

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    Titre
    • Model-based iterative reconstruction in pediatric chest CT: assessment of image quality in a prospective study of children with cystic fibrosis
    Auteur
    • Miéville, Frédéric. Institute of Radiation Physics, Lausanne University Hospital, Grand-Pré 1, 1007, Lausanne, Switzerland
    • Berteloot, Laureline. Department of Pediatric Radiology, Necker Children's Hospital of Paris and University of Paris Descartes, Paris, France
    • Grandjean, Albane. General Electric Medical Systems Europe, Paris, France
    • Ayestaran, Paul. General Electric Medical Systems Europe, Paris, France
    • Gudinchet, François. Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland
    • Schmidt, Sabine. Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland
    • Brunelle, Francis. Department of Pediatric Radiology, Necker Children's Hospital of Paris and University of Paris Descartes, Paris, France
    • Bochud, François. Institute of Radiation Physics, Lausanne University Hospital, Grand-Pré 1, 1007, Lausanne, Switzerland
    • Verdun, Francis. Institute of Radiation Physics, Lausanne University Hospital, Grand-Pré 1, 1007, Lausanne, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317028
    Summary
    Background: The potential effects of ionizing radiation are of particular concern in children. The model-based iterative reconstruction VEOTM is a technique commercialized to improve image quality and reduce noise compared with the filtered back-projection (FBP) method. Objective: To evaluate the potential of VEOTM on diagnostic image quality and dose reduction in pediatric chest CT examinations. Materials and methods: Twenty children (mean 11.4years) with cystic fibrosis underwent either a standard CT or a moderately reduced-dose CT plus a minimum-dose CT performed at 100kVp. Reduced-dose CT examinations consisted of two consecutive acquisitions: one moderately reduced-dose CT with increased noise index (NI = 70) and one minimum-dose CT at CTDIvol 0.14mGy. Standard CTs were reconstructed using the FBP method while low-dose CTs were reconstructed using FBP and VEO. Two senior radiologists evaluated diagnostic image quality independently by scoring anatomical structures using a four-point scale (1=excellent, 2=clear, 3=diminished, 4=non-diagnostic). Standard deviation (SD) and signal-to-noise ratio (SNR) were also computed. Results: At moderately reduced doses, VEO images had significantly lower SD (P < 0.001) and higher SNR (P < 0.05) in comparison to filtered back-projection images. Further improvements were obtained at minimum-dose CT. The best diagnostic image quality was obtained with VEO at minimum-dose CT for the small structures (subpleural vessels and lung fissures) (P < 0.001). The potential for dose reduction was dependent on the diagnostic task because of the modification of the image texture produced by this reconstruction. Conclusions: At minimum-dose CT, VEO enables important dose reduction depending on the clinical indication and makes visible certain small structures that were not perceptible with filtered back-projection