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Functional imaging of head and neck squamous cell carcinoma with diffusion-weighted MRI and FDG PET/CT: quantitative analysis of ADC and SUV

Varoquaux, Arthur ; Rager, Olivier ; Lovblad, Karl-Olof ; Masterson, Karen ; Dulguerov, Pavel ; Ratib, Osman ; Becker, Christoph ; Becker, Minerva

In: European Journal of Nuclear Medicine and Molecular Imaging, 2013, vol. 40, no. 6, p. 842-852

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    Titre
    • Functional imaging of head and neck squamous cell carcinoma with diffusion-weighted MRI and FDG PET/CT: quantitative analysis of ADC and SUV
    Auteur
    • Varoquaux, Arthur. Department of Radiology, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    • Rager, Olivier. Department of Nuclear Medicine, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    • Lovblad, Karl-Olof. Department of Neuroradiology, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    • Masterson, Karen. Department of Radiology, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    • Dulguerov, Pavel. Department of Otorhinolaryngology Head and Neck Surgery, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    • Ratib, Osman. Department of Nuclear Medicine, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    • Becker, Christoph. Department of Radiology, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    • Becker, Minerva. Department of Radiology, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Nuclear Medicine and Molecular Imaging, 2013, vol. 40, no. 6, p. 842-852. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316919
    Summary
    Purpose: Head and neck squamous cell carcinoma (HNSCC) may cause a decreased apparent diffusion coefficient (ADC) on diffusion-weighted magnetic resonance imaging (DW MRI) and an increased standardized uptake value (SUV) on fluorodeoxyglucose (FDG) positron emission tomography (PET/CT). We analysed the reproducibility of ADC and SUV measurements in HNSCC and evaluated whether these biomarkers are correlated or independent. Methods: This retrospective analysis of DW MRI and FDG PET/CT data series included 34 HNSCC in 33 consecutive patients. Two experienced readers measured tumour ADC and SUV values independently. Statistical comparison and correlation with histopathology was done. Intra- and inter-observer agreement for ADC and SUV measurements was assessed. Results: Intraclass correlation coefficient (ICC) analysis showed almost perfect reproducibility (>0.90) for ADCmean, ADCmin, SUVmax and SUVmean values for intra-observer and inter-observer agreement. Mean ADCmean and ADCmin in HNSCC were 1.05 ± 0.34 × 10−3 mm2/s and 0.65 ± 0.29 × 10−3 mm2/s, respectively. Mean SUVmean and mean SUVmax were 7.61 ± 3.87 and 12.8 ± 5.0, respectively. Although statistically not significant, a trend towards higher SUV and lower ADC was observed with increasing tumour dedifferentiation. Pearson's correlation analysis showed no significant correlation between ADC and SUV measurements (r −0.103, −0.051; p 0.552, 0.777). Conclusion: Our data suggest that ADC and SUV values are reproducible and independent biomarkers in HNSCC