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18F-FET PET/CT in Advanced Head and Neck Squamous Cell Carcinoma: an Intra-individual Comparison with 18F-FDG PET/CT

Haerle, Stephan ; Fischer, Dorothee ; Schmid, Daniel ; Ahmad, Nader ; Huber, Gerhard ; Buck, Alfred

In: Molecular Imaging and Biology, 2011, vol. 13, no. 5, p. 1036-1042

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    Titel
    • 18F-FET PET/CT in Advanced Head and Neck Squamous Cell Carcinoma: an Intra-individual Comparison with 18F-FDG PET/CT
    Autor
    • Haerle, Stephan. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, CH-8091, Zurich, Switzerland
    • Fischer, Dorothee. Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, CH-8091, Zurich, Switzerland
    • Schmid, Daniel. Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, CH-8091, Zurich, Switzerland
    • Ahmad, Nader. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, CH-8091, Zurich, Switzerland
    • Huber, Gerhard. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, CH-8091, Zurich, Switzerland
    • Buck, Alfred. Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, CH-8091, Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Molecular Imaging and Biology, 2011, vol. 13, no. 5, p. 1036-1042. Springer-Verlag
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:316899
    Summary
    Purpose: To assess the diagnostic value of O-2-fluoro-18(F)-ethyl-l-tyrosine (18F-FET) positron emission tomography/computed tomography (PET/CT) for patients with advanced head and neck squamous cell carcinoma compared with 18F-fluoro-2-deoxy-d-glucose (18F-FDG) PET/CT at initial staging and following radiochemotherapy. Procedures: Thirteen patients were prospectively enrolled; each of them underwent an 18F-FDG PET/CT and 18F-FET PET/CT before treatment. Ten of those were scanned 10weeks after treatment. Results: Sensitivity, specificity, and accuracy for 18F-FDG PET/CT (primary and lymph node metastases) at initial staging were 89%, 50%, and 81%. For 18F-FET PET/CT the numbers were 70%, 90%, and 74%. Sensitivity, specificity, and accuracy for 18F-FDG PET/CT at follow-up were 71%, 65%, and 67%. For 18F-FET PET/CT the numbers were 29%, 100%, and 83%. Additionally, 18F-FDG PET/CT detected a higher number of second malignancies or distant metastases. Conclusions: 18F-FET is no substitute for 18F-FDG. Although it is more specific, too many malignant lesions are missed due to its lower sensitivity