Fulltext

In vivo confocal microscopy in hydroxychloroquine-induced keratopathy

Dosso, André ; Rungger-Brändle, Elisabeth

In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2007, vol. 245, no. 2, p. 318-320

Add to personal list
    Title
    • In vivo confocal microscopy in hydroxychloroquine-induced keratopathy
    Author
    • Dosso, André. University Eye Clinic, 22 rue Alcide Jentzer, 1211, Geneva 14, Switzerland
    • Rungger-Brändle, Elisabeth. Cell Biology Laboratory, 22 rue Alcide Jentzer, 1211, Geneva 14, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Graefe's Archive for Clinical and Experimental Ophthalmology, 2007, vol. 245, no. 2, p. 318-320. Springer-Verlag
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:316849
    Summary
    Background: Vortex keratopathy, arising as a side effect of several medications, is characterized by golden-brown deposits in the cornea. Methods: A 41-year-old woman treated for sarcoidosis with hydroxychloroquine therapy and suffering from vortex keratopathy was examined by in vivo confocal microscopy. Scans of both corneas were performed. Results: By slit lamp examination, the left but not the right eye showed a golden-brown deposit throughout the cornea. In vivo confocal microscopy revealed the presence of highly reflective, dot-like intracellular inclusions concentrated in the basal epithelial layer. They were also detected within the anterior and posterior stroma, but not within the endothelium. In regions of the anterior stroma, devoid of inclusions, hyperreflective ramified keratocytes were observed, forming an extended interconnecting network. Conclusion: In addition to the granular deposits, in vivo confocal microscopy revealed hyperreflective, possibly phagocytic keratocytes