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Factors Influencing the Success of In Vivo Sentinel Lymph Node Procedure in Colon Cancer Patients : Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer

Viehl, Carsten ; Guller, Ulrich ; Langer, Igor ; Laffer, Urban ; Oertli, Daniel ; Zuber, Markus

In: World Journal of Surgery, 2013, vol. 37, no. 4, p. 873-877

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    Titre
    • Factors Influencing the Success of In Vivo Sentinel Lymph Node Procedure in Colon Cancer Patients
      Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer
    Auteur
    • Viehl, Carsten. Department of Surgery, University Hospital Basel, 4031, Basel, Switzerland
    • Guller, Ulrich. Division of Medical Oncology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
    • Langer, Igor. Department of Surgery, Lindenhof Hospital, Bern, Switzerland
    • Laffer, Urban. Department of Surgery, Hospital Center Biel, Biel, Switzerland
    • Oertli, Daniel. Department of Surgery, University Hospital Basel, 4031, Basel, Switzerland
    • Zuber, Markus. Department of Surgery, Cantonal Hospital Olten, Olten, Switzerland
    Type de document
    • Postprint
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316834
    Summary
    Background: The sentinel lymph node (SLN) procedure has the potential to provide relevant improvement in nodal staging in colon cancer patients. However, there remains room for improvement for SLN identification and sensitivity. Therefore, the objective of the present investigation was to analyze factors influencing the success of the SLN procedure in colon cancer patients. Methods: One hundred seventy-four consecutive colon cancer patients were prospectively enrolled in this multicenter study and underwent in vivo SLN procedure with isosulfan blue 1% followed by open standard oncologic colon resection. Several patient-, tumor-, and procedure-related factors possibly influencing the SLN identification and sensitivity were analyzed. Results: Sentinel lymph node identification rate and accuracy were 89.1 and 83.9%, respectively. Successful identification of SLN was significantly associated with the intraoperative visualization of blue lymphatic vessels (p<0.001) and with female gender (p=0.024). True positive SLN results were significantly associated with higher numbers of SLN (p=0.026) and with pN2 stage (p=0.004). There was a trend toward better sensitivity in patients with lower body mass index (BMI) (p=0.050). Conclusions: The success of the SLN procedure in colon cancer patients depends on both procedure-related factors (intraoperative visualization of blue lymphatic vessels, high number of SLN identified) and patient factors (gender, BMI). While patient factors can not be influenced, intraoperative visualization of blue lymphatics and identification of high numbers of SLN are key for a successful SLN procedure