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Cell cycle regulation by the B-Myb transcription factor

Joaquin, M. ; Watson, R.

In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 11, p. 2389-2401

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    Titre
    • Cell cycle regulation by the B-Myb transcription factor
    Auteur
    • Joaquin, M.. Ludwig Institute for Cancer Research and Department of Virology, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, W2 1PG, London, United Kingdom
    • Watson, R.. Ludwig Institute for Cancer Research and Department of Virology, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, W2 1PG, London, United Kingdom
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 11, p. 2389-2401. Birkhäuser-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316628
    Summary
    The expression of genes required for progression through the cell cycle is highly modulated through a regulatory axis containing the E2F transcription factor and retinoblastoma tumour suppressor protein families. One of the genes regulated through this mechanism encodes the B-Myb transcription factor, which has been shown to be critically required for early embryonal development in the mouse. Transcriptional activity of B-Myb is substantially enhanced in S phase through modification by cyclin A/cdk2, and the evidence points squarely to the major role being played by B-Myb during this phase of the cell cycle. We discuss in this review recent findings suggesting that B-Myb is a multifunctional protein that has, in addition to its transcriptional properties, the ability to interact directly with other regulators of the cell cycle