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Regulation of raft architecture

Harder, T. ; Scheiffele, P.

In: Protoplasma, 2000, vol. 212, no. 1-2, p. 1-7

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    Titre
    • Regulation of raft architecture
    Auteur
    • Harder, T.. Basel Institute for Immunology, Grenzacherstrasse 287, CH-4005, Basel, Switzerland
    • Scheiffele, P.. Department of Molecular and Cell Biology, University of California at Berkeley, California
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Protoplasma, 2000, vol. 212, no. 1-2, p. 1-7. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316595
    Summary
    Summary: Raft membrane domains are envisioned as lateral assemblies of cholesterol and sphingolipids which adopt a liquid-ordered membrane phase. Our understanding of the raft architecture in cell membranes is developing rapidly. The current view describes raft domains as small and highly dynamic subdomains of cell membranes. The size and stability of raft domains are essential parameters which determine the function of raft domains in cells. Here we discuss how the architecture and stability of raft domains is regulated by oligomerisation of raft components and by modulation of their molecular composition