Fulltext

Lymphomatoid granulomatosis in a renal transplant patient

Cachat, François ; Meagher-Villemure, Kathleen ; Guignard, Jean-Pierre

In: Pediatric Nephrology, 2003, vol. 18, no. 8, p. 838-842

Add to personal list
    Title
    • Lymphomatoid granulomatosis in a renal transplant patient
    Author
    • Cachat, François. Department of Pediatrics, University Hospital, Lausanne, Switzerland
    • Meagher-Villemure, Kathleen. Department of Pathology, University Hospital, Lausanne, Switzerland
    • Guignard, Jean-Pierre. Department of Pediatrics, University Hospital, Lausanne, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:316588
    Summary
    Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive pulmonary angiitis considered as a variant of the lymphoproliferative disorder group. Patients with organ transplantation are at an increased risk for post-transplant lymphoproliferative disorders secondary to their immunosuppression. However, lymphomatoid granulomatosis has rarely been described in patients with renal transplantation. It often presents with severe pulmonary signs. We describe a case whose initial presentation was an isolated VIth nerve palsy. We review the radiological and pathological findings and discuss the etiopathogenesis and therapeutic options of this particular lymphoproliferative disorder. With careful and stepwise reduction in her immunosuppression, our patient showed a complete disappearance of her lymphomatoid granulomatosis, and she is clinically well more than 3years after the diagnosis, with good kidney function