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Abnormal Cortical Network Activation in Human Amnesia: A High-resolution Evoked Potential Study

Barcellona-Lehmann, Sandra ; Morand, Stéphanie ; Bindschaedler, Claire ; Nahum, Louis ; Gabriel, Damien ; Schnider, Armin

In: Brain Topography, 2010, vol. 23, no. 1, p. 72-81

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    Titre
    • Abnormal Cortical Network Activation in Human Amnesia: A High-resolution Evoked Potential Study
    Auteur
    • Barcellona-Lehmann, Sandra. Laboratory of Cognitive Neurorehabilitation, Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland
    • Morand, Stéphanie. Laboratory of Cognitive Neurorehabilitation, Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland
    • Bindschaedler, Claire. Division of Neuropsychology and Neurorehabilitation, University Hospital, Lausanne, Switzerland
    • Nahum, Louis. Laboratory of Cognitive Neurorehabilitation, Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland
    • Gabriel, Damien. Laboratory of Cognitive Neurorehabilitation, Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland
    • Schnider, Armin. Laboratory of Cognitive Neurorehabilitation, Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Brain Topography, 2010, vol. 23, no. 1, p. 72-81. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316531
    Summary
    Little is known about how human amnesia affects the activation of cortical networks during memory processing. In this study, we recorded high-density evoked potentials in 12 healthy control subjects and 11 amnesic patients with various types of brain damage affecting the medial temporal lobes, diencephalic structures, or both. Subjects performed a continuous recognition task composed of meaningful designs. Using whole-scalp spatiotemporal mapping techniques, we found that, during the first 200ms following picture presentation, map configuration of amnesics and controls were indistinguishable. Beyond this period, processing significantly differed. Between 200 and 350ms, amnesic patients expressed different topographical maps than controls in response to new and repeated pictures. From 350 to 550ms, healthy subjects showed modulation of the same maps in response to new and repeated items. In amnesics, by contrast, presentation of repeated items induced different maps, indicating distinct cortical processing of new and old information. The study indicates that cortical mechanisms underlying memory formation and re-activation in amnesia fundamentally differ from normal memory processing