Fulltext

Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women

Lippuner, K. ; Johansson, H. ; Kanis, J. ; Rizzoli, R.

In: Osteoporosis International, 2009, vol. 20, no. 7, p. 1131-1140

Aggiungi alla tua lista
    Titre
    • Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women
    Auteur
    • Lippuner, K.. Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, 3010, Bern, Switzerland
    • Johansson, H.. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK
    • Kanis, J.. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK
    • Rizzoli, R.. Division of Bone Diseases, WHO Collaborating Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Osteoporosis International, 2009, vol. 20, no. 7, p. 1131-1140. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316427
    Summary
    Summary: Remaining lifetime and absolute 10-year probabilities for osteoporotic fractures were determined by gender, age, and BMD values. Remaining lifetime probability at age 50years was 20.2% in men and 51.3% in women and increased with advancing age and decreasing BMD. The study validates the elements required to populate a Swiss-specific FRAX® model. Introduction: Switzerland belongs to high-risk countries for osteoporosis. Based on demographic projections, burden will still increase. We assessed remaining lifetime and absolute 10-year probabilities for osteoporotic fractures by gender, age and BMD in order to populate FRAX® algorithm for Switzerland. Methods: Osteoporotic fracture incidence was determined from national epidemiological data for hospitalised fractured patients from the Swiss Federal Office of Statistics in 2000 and results of a prospective Swiss cohort with almost 5,000 fractured patients in 2006. Validated BMD-associated fracture risk was used together with national death incidence and risk tables to determine remaining lifetime and absolute 10-year fracture probabilities for hip and major osteoporotic (hip, spine, distal radius, proximal humerus) fractures. Results: Major osteoporotic fractures incidence was 773 and 2,078 per 100,000 men and women aged 50 and older. Corresponding remaining lifetime probabilities at age 50 were 20.2% and 51.3%. Hospitalisation for clinical spine, distal radius, and proximal humerus fractures reached 25%, 30% and 50%, respectively. Absolute 10-year probability of osteoporotic fracture increased with advancing age and decreasing BMD and was higher in women than in men. Conclusion: This study validates the elements required to populate a Swiss-specific FRAX® model, a country at highest risk for osteoporotic fractures