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FDG uptake in vaginal tampons is caused by urinary contamination and related to tampon position

Burger, Irene ; Scheiner, David ; Crook, David ; Treyer, Valerie ; Hany, Thomas ; von Schulthess, Gustav

In: European Journal of Nuclear Medicine and Molecular Imaging, 2011, vol. 38, no. 1, p. 90-96

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    Titre
    • FDG uptake in vaginal tampons is caused by urinary contamination and related to tampon position
    Auteur
    • Burger, Irene. Division of Nuclear Medicine, Department of Medical Radiology, University Hospital of Zurich, Ramistr. 100, 8091, Zurich, Switzerland
    • Scheiner, David. Division of Obstetrics and Gynecology, University Hospital of Zurich, Zurich, Switzerland
    • Crook, David. Division of Nuclear Medicine, Department of Medical Radiology, University Hospital of Zurich, Ramistr. 100, 8091, Zurich, Switzerland
    • Treyer, Valerie. Division of Nuclear Medicine, Department of Medical Radiology, University Hospital of Zurich, Ramistr. 100, 8091, Zurich, Switzerland
    • Hany, Thomas. Division of Nuclear Medicine, Department of Medical Radiology, University Hospital of Zurich, Ramistr. 100, 8091, Zurich, Switzerland
    • von Schulthess, Gustav. Division of Nuclear Medicine, Department of Medical Radiology, University Hospital of Zurich, Ramistr. 100, 8091, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • European Journal of Nuclear Medicine and Molecular Imaging, 2011, vol. 38, no. 1, p. 90-96. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316323
    Summary
    Purpose: The aim of the study was to determine the aetiology of FDG uptake in vaginal tampons (VT), a known artefact in premenopausal women evaluated by PET/CT. Methods: This Institutional Review Board approved study consisted of retrospective and prospective parts. The retrospective analysis included 685 women examined between January 2008 and December 2009 regarding VT presence. PET/CT images were analysed to determine the localization and the standardized uptake value (SUV) of VTs. We prospectively recruited 24 women (20-48years old) referred for staging or follow-up in an oncology setting between February and April 2010, who were provided a commercial VT to be used during the entire examination after obtaining written informed consent. After image acquisition, VTs were individually analysed for creatinine concentration and blood traces. Statistical significance was tested with the Mann-Whitney U test. Results: In the retrospective part, 38 of 685 women were found to have a VT of which 17 (45%) were FDG positive. A statistically significant correlation was found between FDG activity and VT position below the pubococcygeal line (PCL) (13 ± 11.2mm). In the prospective study, 7 of 24 (29%) women had increased FDG activity in their VTs (SUV 18.8 ± 11g/ml) but were not menstruating. FDG-positive VTs were significantly lower in position (14.6 ± 11.4mm,below the PCL) than FDG-negative VTs (p = 0.039). The creatinine concentration was significantly increased in all seven positive VTs (931 ± 615μmol/l). Conclusion: FDG uptake in VTs is caused by urine contamination, which is likely related to localization below the PCL resulting in contact with urine during voiding