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18F-Fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis

Strobel, Klaus ; Fischer, Dorothee ; Tamborrini, Giorgio ; Kyburz, Diego ; Stumpe, Katrin ; Hesselmann, Rolf ; Johayem, A. ; von Schulthess, Gustav ; Michel, Beat ; Ciurea, Adrian

In: European Journal of Nuclear Medicine and Molecular Imaging, 2010, vol. 37, no. 9, p. 1760-1765

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    Titre
    • 18F-Fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis
    Auteur
    • Strobel, Klaus. Department of Medical Radiology, Division of Nuclear Medicine, University Hospital, Zurich, Switzerland
    • Fischer, Dorothee. Department of Medical Radiology, Division of Nuclear Medicine, University Hospital, Zurich, Switzerland
    • Tamborrini, Giorgio. Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    • Kyburz, Diego. Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    • Stumpe, Katrin. Department of Medical Radiology, Division of Nuclear Medicine, University Hospital, Zurich, Switzerland
    • Hesselmann, Rolf. Radiopharmacy, University Hospital Zurich, Zurich, Switzerland
    • Johayem, A.. Radiopharmacy, University Hospital Zurich, Zurich, Switzerland
    • von Schulthess, Gustav. Department of Medical Radiology, Division of Nuclear Medicine, University Hospital, Zurich, Switzerland
    • Michel, Beat. Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    • Ciurea, Adrian. Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Nuclear Medicine and Molecular Imaging, 2010, vol. 37, no. 9, p. 1760-1765. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315751
    Summary
    Purpose: The aim of this study was to evaluate the performance of 18F-fluoride-PET/CT (PET/CT) for the diagnosis of sacroiliac joint (SIJ) arthritis in patients with active ankylosing spondylitis (AS). Methods: Included in the study were 15 patients with AS according to the modified New York criteria (AS group) and with active disease and 13 patients with mechanical low back pain (MLBP; control group) who were investigated with whole-body 18F-fluoride PET/CT. The ratio of the uptake in the SIJ and that in the sacrum (SIJ/S) was calculated for every joint. Results: The mean SIJ/S ratio of 30 quantified joints in the AS group was 1.66 (range 1.10-3.07) with PET/CT, and the mean SIJ/S ratio of 26 quantified joints in the MLBP group was 1.12 (range 0.71-1.52). The area under the receiver operating characteristic curve for SIJ arthritis was 0.84. With plain radiography as a the gold standard and taking an SIJ/S ratio of >1.3 as the threshold, the sensitivity, specificity and accuracy on a per patient basis were 80%, 77% and 79%, respectively. On a per SIJ basis, the greatest sensitivity (94%) was found in grade 3 sacroiliitis (n = 16). Conclusion: Our results suggest that quantitative 18F-fluoride PET/CT may play a role in the diagnosis of sacroiliitis in active AS and is an alternative to conventional bone scintigraphy in times of molybdenum shortage