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Effects of alcohol consumption on mortality in patients with Type 2 diabetes mellitus

Diem, P. ; Deplazes, M. ; Fajfr, R. ; Bearth, A. ; Müller, B. ; Christ, E. ; Teuscher, A.

In: Diabetologia, 2003, vol. 46, no. 11, p. 1581-1585

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    Titre
    • Effects of alcohol consumption on mortality in patients with Type 2 diabetes mellitus
    Auteur
    • Diem, P.. Division of Endocrinology and Diabetes, University of Bern, Inselspital, 3010, Bern, Switzerland
    • Deplazes, M.. Division of Endocrinology and Diabetes, University of Bern, Inselspital, 3010, Bern, Switzerland
    • Fajfr, R.. Division of Endocrinology and Diabetes, University of Bern, Inselspital, 3010, Bern, Switzerland
    • Bearth, A.. Division of Endocrinology and Diabetes, University of Bern, Inselspital, 3010, Bern, Switzerland
    • Müller, B.. Division of Endocrinology and Diabetes, University of Bern, Inselspital, 3010, Bern, Switzerland
    • Christ, E.. Division of Endocrinology and Diabetes, University of Bern, Inselspital, 3010, Bern, Switzerland
    • Teuscher, A.. Division of Endocrinology and Diabetes, University of Bern, Inselspital, 3010, Bern, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315321
    Summary
    Aims/hypothesis: Moderate alcohol intake has been associated with increased life expectancy due to reduced mortality from cardiovascular disease. We prospectively examined the effects of alcohol consumption on mortality in Type 2 diabetic patients in Switzerland. Methods: A total of 287 patients with Type 2 diabetes mellitus (125 women, 162 men), recruited in Switzerland for the WHO Multinational Study of Vascular Disease in Diabetes, were included in this study. After a follow-up period of 12.6±0.6 years (means ± SD), mortality from CHD and from all causes was assessed. Results: During the follow-up, 70 deaths occurred (21 from CHD, 49 from other causes). Compared with non-drinkers, alcohol consumers who drank alcohol 1 to 15g, 16 to 30g and 30g or more per day had the following risk rates of death from CHD: 0.87 (95% CI: 0.25 to 2.51, NS), 0.00 (95% CI: 0.00 to 0.92, p less than 0.05) and 0.37 (95% CI, 0.01 to 2.42, NS), respectively. The corresponding risk rates of death from all causes were 1.27 (95% CI: 0.68 to 2.28, NS), 0.36 (95% CI: 0.09 to 0.99, p less than 0.05) and 1.66 (95% CI: 0.76 to 3.33, NS). Conclusions/interpretation: In Swiss Type 2 diabetic patients moderate alcohol consumption of 16 to 30g per day was associated with reduced mortality from CHD and from all causes. Alcohol intake above 30g per day was associated with a tendency towards increased all-cause mortality