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Three-dimensional pathological size assessment in primary breast carcinoma

Güth, Uwe ; Brenckle, Denise ; Huang, Dorothy ; Schötzau, Andreas ; Viehl, Carsten ; Dieterich, Holger ; Holzgreve, Wolfgang ; Wight, Edward ; Singer, Gad

In: Breast Cancer Research and Treatment, 2009, vol. 116, no. 2, p. 257-262

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    Titre
    • Three-dimensional pathological size assessment in primary breast carcinoma
    Auteur
    • Güth, Uwe. Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland
    • Brenckle, Denise. Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland
    • Huang, Dorothy. Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland
    • Schötzau, Andreas. JPS Institute for Biomathematics, Malzgasse 9, 4052, Basel, Switzerland
    • Viehl, Carsten. Department of Surgery, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland
    • Dieterich, Holger. Women's Hospital and Breast Center Rheinfelden, Therese-Herzog-Weg 2, 79618, Rheinfelden, Germany
    • Holzgreve, Wolfgang. Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland
    • Wight, Edward. Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031, Basel, Switzerland
    • Singer, Gad. Institute of Pathology, University Hospital Basel (UHB), Schönbeinstrasse 40, 4031, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Breast Cancer Research and Treatment, 2009, vol. 116, no. 2, p. 257-262. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315301
    Summary
    Maximal tumor diameter (MD) is traditionally an important prognostic factor in breast cancer. It must be questioned, however, how well a one-dimensional parameter alone can represent the actual morphologic condition of a three-dimensional body. Along with the pathologically assessed MD and two perpendicular diameters (PDs) of a lesion, eccentricity (EF) and the three-dimensional parameters tumor volume (TV) and surface area (TSA) of 395 ductal invasive breast carcinomas of limited size (10-40mm) were calculated. The dependent prognostic variable was axillary lymph node involvement (ALNI). MD, TV and TSA area were highly significant predictors of ALNI; these variables had similar levels of prediction accuracy (univariate analyses: MD: P=0.0003, TV: P=0.0009, TSA: P<0.0001; multivariate analyses: MD: P=0.0018, TV: P=0.0109, TSA: P=0.0009; pseudo R-squared values: MD: 0.42, TV: 0.39, TSA: 0.39). Despite certain variations in tumor shape, TV and TSA with similar MD, there is no evidence that three-dimensional pathologic measurements (TV/TSA) are more precise prognostic predictors of ALNI compared to the one-dimensional measurement alone