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Simple preparation of76Br,123I and211At labeled 5-halo-2′-deoxyuridine

Koziorowski, J. ; Weinreich, R.

In: Journal of Radioanalytical and Nuclear Chemistry, 1997, vol. 219, no. 1, p. 127-128

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    Titre
    • Simple preparation of76Br,123I and211At labeled 5-halo-2′-deoxyuridine
    Auteur
    • Koziorowski, J.. Institute for Medical Radiobiology, Paul Scherrer Institute, CH-5232, Villigen PSI, Switzerland
    • Weinreich, R.. Institute for Medical Radiobiology, Paul Scherrer Institute, CH-5232, Villigen PSI, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Radioanalytical and Nuclear Chemistry, 1997, vol. 219, no. 1, p. 127-128. Kluwer Academic Publishers
    Autre version électronique
    Classification
    • Chimie
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315220
    Summary
    A fast and easy method for the preparation of radiolabeled 5-halo-2′-deoxyuridine (halo=[76Br], [123I] and [211At]) is presented. Labeling is accomplished by oxidation of the halogenide with Iodogen for [123I] and [211At], and Chloramine-T (CAT) for [76Br] followed by halodestannylation of 5-trimethylstannyl-2′-deoxyuridine (TMSUdR). The reaction takes 1 minute giving >90% yield for all three halogens