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Is there a correlation between 18F-FDG-PET standardized uptake value, T-classification, histological grading and the anatomic subsites in newly diagnosed squamous cell carcinoma of the head and neck?

Haerle, Stephan ; Huber, G. ; Hany, T. ; Ahmad, N. ; Schmid, D.

In: European Archives of Oto-Rhino-Laryngology, 2010, vol. 267, no. 10, p. 1635-1640

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    Titel
    • Is there a correlation between 18F-FDG-PET standardized uptake value, T-classification, histological grading and the anatomic subsites in newly diagnosed squamous cell carcinoma of the head and neck?
    Autor
    • Haerle, Stephan. Department of Otolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Huber, G.. Department of Otolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Hany, T.. Division of Nuclear Medicine, Department of Medical Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland
    • Ahmad, N.. Department of Otolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland
    • Schmid, D.. Division of Nuclear Medicine, Department of Medical Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • European Archives of Oto-Rhino-Laryngology, 2010, vol. 267, no. 10, p. 1635-1640. Springer-Verlag
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:313436
    Summary
    18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET)/CT imaging of squamous cell carcinoma of the head and neck (HNSCC) renders the possibility to study metabolic tumor activity by measuring FDG-uptake expressed as maximum standardized uptake value (SUVmax). A correlation between SUVmax and several factors including T-classification, histological tumor differentiation or different anatomic subsites is of potential interest in HNSCC. The aim of this study was to evaluate how metabolic tumor activity derived from FDG-PET correlates with prognostic clinical and pathological parameters including these factors. 262 patients with HNSCC undergoing PET/CT for initial staging were assessed separately for a potential correlation between SUVmax and T-classification, histological grading, and anatomical subsites of the primary tumor. Nonparametric testing showed a significant correlation between SUVmax and T-classification (P<0.001). On the contrary, no statistically significant correlation was found between SUVmax and histological tumor grading. Furthermore, no statistical significant correlation between the different anatomical subsites and SUVmax were found. There was no significant correlation of SUVmax and tumor grading after adjustment for T-stage and anatomical localization of the tumor, neither. Conclusion: Metabolic tumor activity correlates with T-stage of HNSCC. However, histological tumor grading does not correlate with SUVmax. The role of primary tumor SUVmax as a predictor of outcome or survival remains unclear. Clinicians should therefore exercise caution in attributing any clinical importance to SUVmax obtained from a single PET/CT exam