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Herpes simplex virus hepatitis 4 years after liver transplantation

Bissig, Karl-Dimiter ; Zimmermann, Arthur ; Bernasch, Dirke ; Furrer, Hansjakob ; Dufour, Jean-FranÇois

In: Journal of Gastroenterology, 2003, vol. 38, no. 10, p. 1005-1008

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    Titre
    • Herpes simplex virus hepatitis 4 years after liver transplantation
    Auteur
    • Bissig, Karl-Dimiter. Division of Internal Medicine, Bern, Inselspital, Switzerland
    • Zimmermann, Arthur. Institute of Pathology, Bern, Inselspital, Switzerland
    • Bernasch, Dirke. Institute of Infectious Diseases, Bern, Inselspital, Switzerland
    • Furrer, Hansjakob. Institute of Infectious Diseases, Bern, Inselspital, Switzerland
    • Dufour, Jean-FranÇois. Department of Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Gastroenterology, 2003, vol. 38, no. 10, p. 1005-1008. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:313410
    Summary
    If not promptly recognized and treated, herpes simplex virus (HSV) hepatitis is associated with a high mortality. A patient transplanted for primary sclerosing cholangitis required, 4 years later, a colectomy for a steroid-resistant flare of ulcerative colitis. He subsequently developed fever, with genital and oral ulcerations. He was hospitalized for diabetic decompensation with massive elevation of serum aminotransferases. Examination revealed vesicles on the hands. Liver biopsy showed Cowdry type B inclusions. Therapy with acyclovir was immediately initiated and the patient recovered. This case illustrates the diagnostic importance of mucocutaneous lesions in the assessment of complications after liver transplantation