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Increase in Bone Mineral Density after Successful Parathyroidectomy for Tertiary Hyperparathyroidism after Renal Transplantation

Collaud, Stéphane ; Staub-Zähner, Tania ; Trombetti, Andrea ; Clerici, Thomas ; Marangon, Nicola ; Binet, Isabelle ; Myers, Patrick ; Rizzoli, René ; Martin, Pierre-Yves ; Robert, John ; Triponez, Frederic

In: World Journal of Surgery, 2008, vol. 32, no. 8, p. 1795-1801

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    Titre
    • Increase in Bone Mineral Density after Successful Parathyroidectomy for Tertiary Hyperparathyroidism after Renal Transplantation
    Auteur
    • Collaud, Stéphane. Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Staub-Zähner, Tania. Department of Nephrology, Kantonsspital, 9007, St. Gallen, Switzerland
    • Trombetti, Andrea. Division of Bone Diseases, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Clerici, Thomas. Department of Digestive and Endocrine Surgery, Kantonsspital, 9007, St. Gallen, Switzerland
    • Marangon, Nicola. Department of Nephrology, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Binet, Isabelle. Department of Nephrology, Kantonsspital, 9007, St. Gallen, Switzerland
    • Myers, Patrick. Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Rizzoli, René. Division of Bone Diseases, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Martin, Pierre-Yves. Department of Nephrology, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Robert, John. Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    • Triponez, Frederic. Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • World Journal of Surgery, 2008, vol. 32, no. 8, p. 1795-1801. Springer-Verlag
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:313178
    Summary
    Background: Few studies have reported changes of bone mineral density (BMD) after parathyroidectomy in patients with persistent hyperparathyroidism after renal transplantation (3 HPT). Patients and Methods: We retrospectively analyzed 14 patients who underwent successful parathyroidectomy for 3 HPT and who had available BMD data before and after parathyroidectomy. Results: Median follow-up time was 26months (IQR: 16.8-40.2). Serum calcium levels decreased significantly after parathyroidectomy (2.32 ± 0.09 versus 2.66±0.16mmol/l; p<0.01), as did PTH levels (5.1±3.0 versus 27.8±23.7pmol/l; p<0.01). Nine patients (64%) had a steroid-free immunosuppression at follow-up. Mean increase in BMD was 9.5±8.0% for the spine and 9.5±7.9% for the hip (p<0.01 for both sites). Patients with osteoporosis (T-score ≤ 2.5) or osteopenia (T-score ≤ 1) before parathyroidectomy had the biggest increase in BMD (10.7±7.7% in hip BMD and of 12.3±8.1% in spine BMD). Conclusions: Parathyroidectomy is an efficient treatment of osteoporosis and osteopenia in patients with 3 HPT