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Rare suprasellar glioblastoma: report of two cases and review of the literature

Lemm, Doreen ; de Oliveira, Francine ; Bernays, René-Ludwig ; Kockro, Ralf ; Kollias, Spyros ; Fischer, Ingeborg ; Rushing, Elisabeth

In: Brain Tumor Pathology, 2012, vol. 29, no. 4, p. 216-220

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    Titre
    • Rare suprasellar glioblastoma: report of two cases and review of the literature
    Auteur
    • Lemm, Doreen. Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    • de Oliveira, Francine. Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    • Bernays, René-Ludwig. Department of Neurosurgery, University Hospital Zurich, 8091, Zurich, Switzerland
    • Kockro, Ralf. Department of Neurosurgery, University Hospital Zurich, 8091, Zurich, Switzerland
    • Kollias, Spyros. Institute of Neuroradiology, University Hospital Zurich, 8091, Zurich, Switzerland
    • Fischer, Ingeborg. Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    • Rushing, Elisabeth. Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:313139
    Summary
    Background and importance: The suprasellar and hypothalamic/chiasmatic regions can harbor a broad range of pathologic conditions, both neoplastic and nonneoplastic; however, malignant gliomas are extremely rare in those regions. Clinical presentations: Patient 1 was a 70year-old man with weight loss and rapidly progressive visual impairment. A mass centered in the hypothalamus was detected on magnetic resonance (MR) imaging. The second patient, a 45year-old woman, complained of visual symptoms and headaches. MR imaging revealed a combined intra- and suprasellar mass. In both instances, the preoperative differential diagnosis favored craniopharyngioma. Histological examination confirmed the diagnosis of glioblastoma. Conclusion: We report two rare adult cases of hypothalamic/chiasmatic glioblastoma. The authors review the literature, highlighting the importance of considering this rare entity in the differential diagnosis of suprasellar and hypothalamic lesions