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MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects

Jilek, Samantha ; Schluep, Myriam ; Pantaleo, Giuseppe ; Du Pasquier, Renaud

In: Neurological Sciences, 2013, vol. 34, no. 4, p. 539-543

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    Title
    • MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects
    Author
    • Jilek, Samantha. Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011, Lausanne, Switzerland
    • Schluep, Myriam. Division of Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011, Lausanne, Switzerland
    • Pantaleo, Giuseppe. Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011, Lausanne, Switzerland
    • Du Pasquier, Renaud. Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011, Lausanne, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:313121
    Summary
    Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Myelin oligodendrocyte glycoprotein (MOG) and myelin oligodendrocyte basic protein (MOBP) were both shown to be highly encephalitogenic in animal models of MS. In contrast, the association of MOG- and MOBP-specific humoral or cellular immune responses and MS in humans is far less established. In this study, we sought to analyse MOG- and MOBP-specific T-cell responses in a large cohort of patients with various stages of the disease. Patients with other neurological diseases and healthy subjects were enrolled to serve as control study subjects. We determined the proliferation and the secretion of IFN-γ secretion in our cohort. We found that MOG-specific T-cell responses were higher and more frequent as compared to MOBP-specific ones. However, both MS patients and control study subjects had similar myelin-specific T-cell responses at the periphery, thus calling for more precise studies at CNS level