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Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

Storek, Jan ; Geddes, Michelle ; Khan, Faisal ; Huard, Bertrand ; Helg, Claudine ; Chalandon, Yves ; Passweg, Jakob ; Roosnek, Eddy

In: Seminars in Immunopathology, 2008, vol. 30, no. 4, p. 425-437

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    Titre
    • Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
    Auteur
    • Storek, Jan. Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada
    • Geddes, Michelle. Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada
    • Khan, Faisal. Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada
    • Huard, Bertrand. Division of Hematology, Department of Internal Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    • Helg, Claudine. Division of Hematology, Department of Internal Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    • Chalandon, Yves. Division of Hematology, Department of Internal Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    • Passweg, Jakob. Division of Hematology, Department of Internal Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    • Roosnek, Eddy. Division of Hematology, Department of Internal Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Seminars in Immunopathology, 2008, vol. 30, no. 4, p. 425-437. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:312384
    Summary
    Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery