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Primary pulmonary malignant meningioma with lymph node and liver metastasis in a centenary woman, an autopsy case

Weber, Catherine ; Pautex, Sophie ; Zulian, Gilbert ; Pusztaszeri, Marc ; Lobrinus, Johannes

In: Virchows Archiv, 2013, vol. 462, no. 4, p. 481-485

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    Titre
    • Primary pulmonary malignant meningioma with lymph node and liver metastasis in a centenary woman, an autopsy case
    Auteur
    • Weber, Catherine. Division of Primary Care, University Hospital Geneva, Geneva, Switzerland
    • Pautex, Sophie. Division of Primary Care, University Hospital Geneva, Geneva, Switzerland
    • Zulian, Gilbert. Division of Palliative Medicine, University Hospital Geneva, Geneva, Switzerland
    • Pusztaszeri, Marc. Department of Clinical Pathology, University Hospital Geneva, CMU - 1, rue Michel-Servet, 1211, Geneva 4, Switzerland
    • Lobrinus, Johannes. Department of Clinical Pathology, University Hospital Geneva, CMU - 1, rue Michel-Servet, 1211, Geneva 4, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:312076
    Summary
    Primary meningiomas arising outside the central nervous system are very rare. They have been reported in the head and neck region, in the thorax, the retroperitoneum, and the pelvis. Usually, they behave as slow-growing tumors with a good prognosis. Herein, we report an autopsy case of a 108-year-old woman, known for a right-sided slowly growing lung nodule for 39years. Death was attributed to cachexia. At post-mortem, a 15-cm mass was present in the right inferior lobe of the lung, associated with an ipsilateral hilar lymphadenopathy, and another 10-cm mass in the liver. Histology revealed a WHO grade III meningioma. No tumor was observed in the cranial cavity. This case illustrates a rare location of meningioma and highlights its biological behavior, with a very slow progression from a most probably benign tumor to a malignant lesion with metastasis over four decades