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Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters

Therrien, Bruno ; Ang, Wee ; Chérioux, Frédéric ; Vieille-Petit, Ludovic ; Juillerat-Jeanneret, Lucienne ; Süss-Fink, Georg ; Dyson, Paul

In: Journal of Cluster Science, 2007, vol. 18, no. 3, p. 741-752

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    Title
    • Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters
    Author
    • Therrien, Bruno. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009, Neuchâtel, Switzerland
    • Ang, Wee. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland
    • Chérioux, Frédéric. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009, Neuchâtel, Switzerland
    • Vieille-Petit, Ludovic. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009, Neuchâtel, Switzerland
    • Juillerat-Jeanneret, Lucienne. Centre Hospitalier Universitaire Vaudois (CHUV), University Institute of Pathology, 1011, Lausanne, Switzerland
    • Süss-Fink, Georg. Institut de Chimie, Université de Neuchâtel, Case postale 158, 2009, Neuchâtel, Switzerland
    • Dyson, Paul. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Cluster Science, 2007, vol. 18, no. 3, p. 741-752. Springer US; http://www.springer-ny.com
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:311083
    Summary
    The invitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)4Ru4(μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4(μ-H)4][BF4]2 and [(η6-C6H6)4Ru4(μ-H)3(μ-OH)][Cl]2, has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(η6-C6H5Me)4Ru4(μ-H)4][PF6]2 is also reported. Graphical Abstract: The invitro activity of a series of ruthenium clusters has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines and their activity compared to cisplatin. The triruthenium clusters are very active, while the tetraruthenium clusters do not display significant cytotoxicities