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Decrease in Hemoglobin Levels Following Surgery Influences the Outcome in Head and Neck Cancer Patients Treated with Accelerated Postoperative Radiotherapy

Pehlivan, Berrin ; Zouhair, Abderrahim ; Luthi, François ; Bron, Luc ; Pasche, Philippe ; Dragusanu, Daniela ; Azria, David ; Matzinger, Oscar ; Mirimanoff, René ; Ozsahin, Mahmut

In: Annals of Surgical Oncology, 2009, vol. 16, no. 5, p. 1331-1336

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    Titel
    • Decrease in Hemoglobin Levels Following Surgery Influences the Outcome in Head and Neck Cancer Patients Treated with Accelerated Postoperative Radiotherapy
    Autor
    • Pehlivan, Berrin. Radiation Oncology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Zouhair, Abderrahim. Radiation Oncology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Luthi, François. Medical Oncology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Bron, Luc. Otolaryngology-Head and Neck Surgery, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Pasche, Philippe. Otolaryngology-Head and Neck Surgery, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Dragusanu, Daniela. Radiation Oncology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Azria, David. Radiation Oncology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Matzinger, Oscar. Radiation Oncology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Mirimanoff, René. Radiation Oncology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • Ozsahin, Mahmut. Radiation Oncology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Annals of Surgical Oncology, 2009, vol. 16, no. 5, p. 1331-1336. Springer-Verlag
    Andere elektronische Ausgabe
    Klassifikation
    • Gesundheit
    OAI-PMH-ID
    • oai:doc.rero.ch:310965
    Summary
    Aim: To assess the influence of hemoglobin (Hb) levels in locally advanced head and neck cancer (LAHNC) patients treated with surgery and postoperative radiotherapy (PORT). Material and Methods: Pre- and postoperative Hb levels were collected in 79 patients treated with surgery followed by accelerated PORT for LAHNC. Median follow-up was 52months (range 12-95months). Results and Discussion: Four-year overall survival (OS) rate was 51%. Neither pre- nor postoperative Hb level (<120 or 130g/l in women or men, respectively) influenced the outcome. However, when Hb decrease between pre- and postoperative Hb values was taken into account, 4-year OS was significantly higher in patients with Hb difference less than 38g/l (quartile value) compared with those with Hb decrease 38g/l or more (61% versus 16%, P=0.008). Conclusion: Decrease in Hb level by more than 38g/l after surgery secondary to blood loss influences the outcome when postoperative RT is indicated