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18F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PET

Wyss, Matthias ; Weber, Bruno ; Honer, Michael ; Späth, Nicolas ; Ametamey, Simon ; Westera, Gerrit ; Bode, Beata ; Kaim, Achim ; Buck, Alfred

In: European Journal of Nuclear Medicine and Molecular Imaging, 2004, vol. 31, no. 3, p. 312-316

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    Titre
    • 18F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PET
    Auteur
    • Wyss, Matthias. PET Center, Division of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    • Weber, Bruno. PET Center, Division of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    • Honer, Michael. Center for Radiopharmaceutical Science of ETH, PSI and USZ, Paul Scherrer Institute, Villigen, Switzerland
    • Späth, Nicolas. PET Center, Division of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    • Ametamey, Simon. Center for Radiopharmaceutical Science of ETH, PSI and USZ, Paul Scherrer Institute, Villigen, Switzerland
    • Westera, Gerrit. Center for Radiopharmaceutical Science of ETH, PSI and USZ, Paul Scherrer Institute, Villigen, Switzerland
    • Bode, Beata. Institute of Pathology, University Hospital, Zurich, Switzerland
    • Kaim, Achim. Klinik Im Schachen, Schänisweg, Aarau, Switzerland
    • Buck, Alfred. PET Center, Division of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Nuclear Medicine and Molecular Imaging, 2004, vol. 31, no. 3, p. 312-316. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:310147
    Summary
    For each oncological tracer it is important to know the uptake in non-tumorous lesions. The purpose of this study was to measure the accumulation of fluorine-18 choline (FCH), a promising agent for the evaluation of certain tumour types, in infectious tissue. Unilateral thigh muscle abscesses were induced in five rats by intramuscular injection of 0.1ml of a bacterial suspension (Staphylococcus aureus, 1.2×109CFU/ml). In all animals, FCH accumulation was measured with high-resolution positron emission tomography (PET) on day 6. Autoradiography of the abscess and ipsilateral healthy muscle was performed on day 7 (three animals) and day 11 (two animals) and correlated with histology. In addition, 18F-fluorodeoxyglucose (FDG) PET was performed on day 5. Increased FCH uptake was noted in specific layers of the abscess wall which contained an infiltrate of mainly granulocytes on day 7 and mainly macrophages on day 11. The autoradiographic standardised uptake values in the most active part of the abscess wall were 2.99 on day 7 (n=3) and 4.05 on day 11 (n=2). In healthy muscle the corresponding values were 0.99 and 0.64. The abscesses were clearly visualised on the FCH and FDG PET images. In conclusion, this study demonstrated avid FCH accumulation in inflammatory tissue, which limits the specificity of FCH for tumour detection. Future studies are now needed to determine the degree of this limitation in human cancer patients