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Strand separation in negatively supercoiled DNA

Mazza, Christian

In: Journal of Mathematical Biology, 2005, vol. 51, no. 2, p. 198-216

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    Titre
    • Strand separation in negatively supercoiled DNA
    Auteur
    • Mazza, Christian. Section de Mathématiques, 2-4 Rue du Lièvre, CP 64 CH-1211, Genève 4, Suisse
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Mathematical Biology, 2005, vol. 51, no. 2, p. 198-216. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:309925
    Summary
    Abstract.: We consider Benham's model for strand separation in negatively supercoiled circular DNA, and study denaturation as function of the linking difference density κ<0. We propose a statistical version of this model, based on bayesian segmentation methods of current use in bioinformatics; this leads to new algorithms with priors adapted to supercoiled DNA, taking into account the random nature of the free energies needed to denature base pairs