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Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations

Rossi, Isabelle ; Bochud, Murielle ; Bovet, Pascal ; Paccaud, Fred ; Waeber, Gérard ; Vollenweider, Peter ; Taffé, Patrick

In: European Journal of Epidemiology, 2012, vol. 27, no. 5, p. 379-384

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    Titre
    • Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations
    Auteur
    • Rossi, Isabelle. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital and University of Lausanne, Route de la Corniche 2, 1066, Epalinges, Switzerland
    • Bochud, Murielle. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital and University of Lausanne, Route de la Corniche 2, 1066, Epalinges, Switzerland
    • Bovet, Pascal. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital and University of Lausanne, Route de la Corniche 2, 1066, Epalinges, Switzerland
    • Paccaud, Fred. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital and University of Lausanne, Route de la Corniche 2, 1066, Epalinges, Switzerland
    • Waeber, Gérard. Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011, Lausanne, Switzerland
    • Vollenweider, Peter. Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011, Lausanne, Switzerland
    • Taffé, Patrick. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital and University of Lausanne, Route de la Corniche 2, 1066, Epalinges, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Epidemiology, 2012, vol. 27, no. 5, p. 379-384. Springer Netherlands
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:309878
    Summary
    Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extensively demonstrated and correlations are stronger in women than men. We used fractional polynomials—a method that allows flexible modeling of non linear relations—to investigate the dose/response mathematical relationship between hs-CRP and several indicators of adiposity in Caucasians (Switzerland) and Africans (Seychelles) surveyed in two population-based studies. This relationship was non-linear exhibiting a steeper slope for low levels of hs-CRP and a higher level in women. The observed sex difference in the relationship between hs-CRP and adiposity almost disappeared upon adjustment for leptin, suggesting that these sex differences might be partially mediated, by leptin. All these relationship were similar in Caucasians and Africans. This is the first report on a non-linear relation, stratified by gender, between hs-CRP and adiposity