000030602 001__ 30602
000030602 005__ 20131002114018.0
000030602 0248_ $$aoai:doc.rero.ch:20121115114247-RA$$punifr$$ppostprint$$prero_explore$$zcdu34$$zthesis_urn$$zcdu57$$zreport$$zthesis$$zbook$$zjournal$$zcdu16$$zpreprint$$zcdu1$$zdissertation
000030602 041__ $$aeng
000030602 080__ $$a57
000030602 100__ $$aFavre, Guillaume$$uDepartment of Medicine, Laboratory of Brain and Cognitive Development, University of Fribourg, Switzerland
000030602 245__ $$9eng$$aDevelopmental regulation of expression of schizophrenia susceptibility genes in the primate hippocampal formation
000030602 269__ $$c2012-10-23
000030602 520__ $$9eng$$aThe hippocampal formation is essential for normal memory function and is implicated in many neurodevelopmental, neurodegenerative and neuropsychiatric disorders. In particular, abnormalities in hippocampal structure and function have been identified in schizophrenic subjects. Schizophrenia has a strong polygenic component, but the role of numerous susceptibility genes in normal brain development and function has yet to be investigated. Here we described the expression of schizophrenia susceptibility genes in distinct regions of the monkey hippocampal formation during early postnatal development. We found that, as compared with other genes, schizophrenia susceptibility genes exhibit a differential regulation of expression in the dentate gyrus, CA3 and CA1, over the course of postnatal development. A number of these genes involved in synaptic transmission and dendritic morphology exhibit a developmental decrease of expression in CA3. Abnormal CA3 synaptic organization observed in schizophrenics might be related to some specific symptoms, such as loosening of association. Interestingly, changes in gene expression in CA3 might occur at a time possibly corresponding to the late appearance of the first clinical symptoms. We also found earlier changes in expression of schizophrenia susceptibility genes in CA1, which might be linked to prodromal psychotic symptoms. A number of schizophrenia susceptibility genes including APOE, BDNF, MTHFR and SLC6A4 are involved in other disorders, and thus likely contribute to nonspecific changes in hippocampal structure and function that must be combined with the dysregulation of other genes in order to lead to schizophrenia pathogenesis.
000030602 695__ $$9eng$$aAlzheimer ; autism spectrum disorder ; epilepsy ; hippocampus ; schizophrenia ; Williams
000030602 700__ $$aLavenex, Pamela Banta$$uDepartment of Medicine, Laboratory of Brain and Cognitive Development, University of Fribourg, Switzerland - Laboratory for Experimental Research on Behavior, Institute of Psychology, University of Lausanne, Switzerland
000030602 700__ $$aLavenex, Pierre$$uDepartment of Medicine, Laboratory of Brain and Cognitive Development, University of Fribourg, Switzerland - Laboratory for Experimental Research on Behavior, Institute of Psychology, University of Lausanne, Switzerland
000030602 773__ $$g2012/2//e173$$tTranslational Psychiatry
000030602 775__ $$gPublished version$$ohttp://dx.doi.org/10.1038/tp.2012.105
000030602 8564_ $$flav_dre.pdf$$qapplication/pdf$$s689410$$uhttp://doc.rero.ch/record/30602/files/lav_dre.pdf$$yorder:1$$zpdf
000030602 8564_ $$flav_dre_sm.pdf$$qapplication/pdf$$s864580$$uhttp://doc.rero.ch/record/30602/files/lav_dre_sm.pdf$$yorder:2$$zSupplementary material
000030602 918__ $$aFaculté des sciences$$bDécanat, Ch. du Musée 6A, 1700 Fribourg$$cMédecine
000030602 919__ $$aUniversité de Fribourg$$bFribourg$$ddoc.support@rero.ch
000030602 980__ $$aPOSTPRINT$$bUNIFR$$fART_JOURNAL
000030602 990__ $$a20121115114247-RA