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Reproducibility of 3D free-breathing magnetic resonance coronary vessel wall imaging

Desai, Milind Y. ; Lai, Shenghan ; Barmet, Christoph ; Weiss, Robert G. ; Stuber, Matthias

In: European Heart Journal, 2005, vol. 26, no. 21, p. 2320-2324

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    Titre
    • Reproducibility of 3D free-breathing magnetic resonance coronary vessel wall imaging
    Auteur
    • Desai, Milind Y.. Russell. H. Morgan Department of Radiology and Radiologic Sciences, Johns Hopkins University Medical School, JHOC 4243, 601, North Caroline Street, Baltimore, MD 21287, USA
    • Lai, Shenghan. Department of Pathology, Johns Hopkins University Medical School, JHOC 4243, 601, North Caroline Street, Baltimore, MD 21287, USA
    • Barmet, Christoph. Institute of Biomedical Engineering, University and ETH, Zurich, Switzerland
    • Weiss, Robert G.. Department of Medicine, Johns Hopkins University Medical School, JHOC 4243, 601, North Caroline Street, Baltimore, MD 21287, USA
    • Stuber, Matthias. Russell. H. Morgan Department of Radiology and Radiologic Sciences, Johns Hopkins University Medical School, JHOC 4243, 601, North Caroline Street, Baltimore, MD 21287, USA
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Heart Journal, 2005, vol. 26, no. 21, p. 2320-2324. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:304925
    Summary
    Aims Although the coronary artery vessel wall can be imaged non-invasively using magnetic resonance imaging (MRI), the in vivo reproducibility of wall thickness measures has not been previously investigated. Using a refined magnetization preparation scheme, we sought to assess the reproducibility of three-dimensional (3D) free-breathing black-blood coronary MRI in vivo. Methods and results MRI vessel wall scans parallel to the right coronary artery (RCA) were obtained in 18 healthy individuals (age range 25-43, six women), with no known history of coronary artery disease, using a 3D dual-inversion navigator-gated black-blood spiral imaging sequence. Vessel wall scans were repeated 1 month later in eight subjects. The visible vessel wall segment and the wall thickness were quantitatively assessed using a semi-automatic tool and the intra-observer, inter-observer, and inter-scan reproducibilities were determined. The average imaged length of the RCA vessel wall was 44.5±7 mm. The average wall thickness was 1.6±0.2 mm. There was a highly significant intra-observer (r=0.97), inter-observer (r=0.94), and inter-scan (r=0.90) correlation for wall thickness (all P<0.001). There was also a significant agreement for intra-observer, inter-observer, and inter-scan measurements on Bland-Altman analysis. The intra-class correlation coefficients for intra-observer (r=0.97), inter-observer (r=0.92), and inter-scan (r=0.86) analyses were also excellent. Conclusion The use of black-blood free-breathing 3D MRI in conjunction with semi-automated analysis software allows for reproducible measurements of right coronary arterial vessel-wall thickness. This technique may be well-suited for non-invasive longitudinal studies of coronary atherosclerosis