Incidence of HIV-1 Drug Resistance Among Antiretroviral Treatment-Naive Individuals Starting Modern Therapy Combinations

von Wyl, Viktor ; Yerly, Sabine ; Böni, Jürg ; Shah, Cyril ; Cellerai, Cristina ; Klimkait, Thomas ; Battegay, Manuel ; Bernasconi, Enos ; Cavassini, Matthias ; Furrer, Hansjakob ; Hirschel, Bernard ; Vernazza, Pietro L. ; Ledergerber, Bruno ; Günthard, Huldrych F.

In: Clinical Infectious Diseases, 2012, vol. 54, no. 1, p. 131-140

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    By use of simulations we imputed human immunodeficiency virus type 1 drug resistance incidence to protease inhibitor-based or nonnucleoside reverse-transcriptase inhibitor-based combination therapy. We found that novel drugs such as tenofovir or boosted atazanavir lead to less drug resistance, most likely because of better tolerability