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Humoral Response to the Influenza A H1N1/09 Monovalent AS03-Adjuvanted Vaccine in Immunocompromised Patients

Manuel, Oriol ; Pascual, Manuel ; Hoschler, Katja ; Giulieri, Stefano ; Alves, Deolinda ; Ellefsen, Kim ; Bart, Pierre-Alexandre ; Venetz, Jean-Pierre ; Calandra, Thierry ; Cavassini, Matthias

In: Clinical Infectious Diseases, 2011, vol. 52, no. 2, p. 248-256

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    Title
    • Humoral Response to the Influenza A H1N1/09 Monovalent AS03-Adjuvanted Vaccine in Immunocompromised Patients
    Author
    • Manuel, Oriol. Transplantation Center
    • Pascual, Manuel. Transplantation Center
    • Hoschler, Katja. Health Protection Agency, London, United Kingdom
    • Giulieri, Stefano. Infectious Diseases Service
    • Alves, Deolinda. Infectious Diseases Service
    • Ellefsen, Kim. Division of Immunology and Allergy, University Hospital of Lausanne (CHUV) and University of Lausanne, Switzerland
    • Bart, Pierre-Alexandre. Division of Immunology and Allergy, University Hospital of Lausanne (CHUV) and University of Lausanne, Switzerland
    • Venetz, Jean-Pierre. Transplantation Center
    • Calandra, Thierry. Infectious Diseases Service
    • Cavassini, Matthias. Infectious Diseases Service
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 2011, vol. 52, no. 2, p. 248-256. Oxford University Press
    Other Version
    Classification
    • Health
    Keywords
    OAI-PMH Identifier
    • oai:doc.rero.ch:304783
    Summary
    In this observational study, safety and immunogenicity after one dose of the AS03-adjuvanted influenza H1N1/09 vaccine was overall appropriate in HIV-infected patients and solid-organ transplant recipients. A second dose of the vaccine only moderately improved the antibody response