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The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease

Glas, Jürgen ; Török, Helga-Paula ; Tonenchi, Laurian ; Wetzke, Martin ; Beynon, Vanessa ; Teshome, Molla Y. ; Cotofana, Sebastian ; Schiemann, Uwe ; Griga, Thomas ; Klein, Wolfram ; Epplen, Joerg T. ; Folwaczny, Christian ; Folwaczny, Matthias ; Mussack, Thomas ; Weiss, Elisabeth H.

In: International Immunology, 2007, vol. 19, no. 5, p. 621-626

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    Titel
    • The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease
    Autor
    • Glas, Jürgen. Chirurgische Klinik und Poliklinik-Innenstadt
    • Török, Helga-Paula. Chirurgische Klinik und Poliklinik-Innenstadt
    • Tonenchi, Laurian. Chirurgische Klinik und Poliklinik-Innenstadt
    • Wetzke, Martin. Chirurgische Klinik und Poliklinik-Innenstadt
    • Beynon, Vanessa. Chirurgische Klinik und Poliklinik-Innenstadt
    • Teshome, Molla Y.. Chirurgische Klinik und Poliklinik-Innenstadt
    • Cotofana, Sebastian. Chirurgische Klinik und Poliklinik-Innenstadt
    • Schiemann, Uwe. Klinik für Allgemeine Innere Medizin, Inselspital Bern, Bern, Switzerland
    • Griga, Thomas. Medizinische Klinik-Innere Medizin, Knappschaftskrankenhaus Dortmund, Dortmund, Germany
    • Klein, Wolfram. Abteilung für Humangenetik, Ruhr-Universität Bochum, Bochum, Germany
    • Epplen, Joerg T.. Abteilung für Humangenetik, Ruhr-Universität Bochum, Bochum, Germany
    • Folwaczny, Christian. Chirurgische Klinik und Poliklinik-Innenstadt
    • Folwaczny, Matthias. Poliklinik für Zahnerhaltung und Parodontologie, Klinikum der Universität München, Munich, Germany
    • Mussack, Thomas. Chirurgische Klinik und Poliklinik-Innenstadt
    • Weiss, Elisabeth H.. Department Biologie II, Anthropologie und Humangenetik, Ludwig-Maximilians-Universität München, Munich, Germany
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • International Immunology, 2007, vol. 19, no. 5, p. 621-626. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:304734
    Summary
    HLA-G is a non-classical MHC class Ib molecule predominantly expressed in cytotrophoblasts and under pathological conditions also in chronically inflamed and in malignant tissues. Recently an increased expression of HLA-G was found in ulcerative colitis (UC), but not in Crohn's disease (CD). The HLA-G gene is located in IBD3, a linkage region for inflammatory bowel disease (IBD). A 14-bp deletion polymorphism (Del+/Del−) within exon 8 of the HLA-G gene might influence transcription activity and is therefore of potential functional relevance. To investigate whether the 14-bp deletion polymorphism is associated with IBD, 371 patients with CD, 257 patients with UC and 739 controls were genotyped. The heterozygous genotype (P = 0.031) and the Del+ phenotype (P = 0.038) were significantly increased, whereas the homozygous Del− phenotype (P = 0.038) was significantly decreased in UC when compared with CD. Thus, the 14-bp deletion polymorphism within the HLA-G gene displayed significant differences between UC and CD. Moreover, a significant increase of the Del+ allele (P = 0.002) and the Del+/Del+ genotype (P = 0.013) and a consecutive decrease of the Del−/− genotype (P = 0.024) were observed in those CD cases positive for ileocecal resection. Thus, a potential effect of the HLA-G gene in IBD may affect both UC and CD. Other polymorphisms linked to the 14-bp deletion polymorphism might also contribute to immunopathogenesis. As there are several partly functional polymorphisms within the promoter region potentially influencing HLA-G expression, further studies in IBD are necessary in the context of differential expression of HLA-G between UC and CD