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Influence of the consumption pattern of magnesium from magnesium-rich mineral water on magnesium bioavailability

Sabatier, Magalie ; Grandvuillemin, Antoine ; Kastenmayer, Peter ; Aeschliman, Jean-Marc ; Bouisset, Florilène ; Arnaud, Maurice J. ; Dumoulin, Gilles ; Berthelot, Alain

In: British Journal of Nutrition, 2011, vol. 106, no. 3, p. 331-334

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    Titre
    • Influence of the consumption pattern of magnesium from magnesium-rich mineral water on magnesium bioavailability
    Auteur
    • Sabatier, Magalie. Nestlé Research Center, Lausanne, Switzerland
    • Grandvuillemin, Antoine. Laboratoire de Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, U.F.R. Médecine-Pharmacie, Besançon, France
    • Kastenmayer, Peter. Nestlé Research Center, Lausanne, Switzerland
    • Aeschliman, Jean-Marc. Nestlé Research Center, Lausanne, Switzerland
    • Bouisset, Florilène. Nestlé Research Center, Lausanne, Switzerland
    • Arnaud, Maurice J.. Nestlé Water Institute, Vittel, France
    • Dumoulin, Gilles. Laboratoire de Physiologie et d'Exploration Fonctionnelle Rénale Métabolique et Endocrinienne, C.H.U., Besançon, France
    • Berthelot, Alain. Laboratoire de Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, U.F.R. Médecine-Pharmacie, Besançon, France
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • British Journal of Nutrition, 2011, vol. 106, no. 3, p. 331-334. Cambridge University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:304400
    Summary
    It is generally considered that the absorption of Mg is inversely related to the ingested dose. The objective of the present study was to determine if the mode of administration (bolus v. consumption throughout the day) could influence Mg bioavailability from Mg-rich natural mineral water comparing the same nutritional Mg amount (126mg). Using a 2d cross-over design, twelve healthy men were asked to drink 1·5 litres Mg-rich mineral water either as 2×750ml or 7×212ml throughout the day. Two stable isotopes (25Mg and 26Mg) were used to label the water in order to distinguish both regimens. Fractional apparent Mg absorption was determined by faecal monitoring and Mg retention was determined by measuring urinary excretion of Mg isotopes. Higher Mg absorption (50·7 (sd 12·7) v. 32·4 (sd 8·1) %; P=0·0007) and retention (47·5 (sd 12·9) v. 29·0 (sd 7·5) %; P=0·0008) from Mg-rich mineral water were observed when it was consumed in seven servings compared with larger servings. Thus, regular water consumption throughout the day is an effective way to increase Mg bioavailability from Mg-rich mineral water