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Rheumatoid arthritis - treatment : 180. Utility of Body Weight Classified Low-Dose Leflunomide in Japanese Rheumatoid Arthritis

Nishikawa, Masataka ; Owaki, Hajime ; Fuji, Takeshi ; Soliman, Moetaza M. ; Ashcroft, Darren M. ; Watson, Kath D. ; Lunt, Mark ; Symmons, Deborah ; Hyrich, Kimme L. ; Atkinson, Francesca ; Malik, Saadia ; Heycock, Carol ; Saravanan, Vadivelu ; Rynne, Martin ; Hamilton, Jennifer ; Kelly, Clive ; Burmester, Gerd ; Kary, Sonja ; Unnebrink, Kristina ; Guérette, Benoit ; Oezer, Uemit ; Kupper, Hartmut ; Dennison, Elaine ; Jameson, Karen ; Hyrich, Kimme ; Watson, Kath ; Landewe, Robert ; Keystone, Edward ; Smolen, Josef ; Goldring, Mary ; Guérette, Benoit ; Patra, Kaushik ; Cifaldi, Mary ; van der Heijde, Désirée ; Lloyd, Lois A. ; Owen, Catherine ; Breslin, Anne ; Ahmad, Yasmeen ; Emery, Paul ; Matteson, E. L. ; Genovese, M. ; Sague, S. ; Hsia, E. C. ; Doyle, M. K. ; Fan, H. ; Elashoff, M. ; Kirkham, Bruce ; Wasco, M. C. ; Bathon, J. ; Hsia, E. C. ; Fleischmann, R. ; Genovese, M. C. ; Matteson, E. L. ; Liu, H. ; Fleischmann, R. ; Goldman, J. ; Leirisalo-Repo, M. ; Zanetakis, E. ; El-Kadi, H. ; Kellner, H. ; Bolce, R. ; Wang, J. ; Dehoratius, R. ; Decktor, D. ; Kremer, J. ; Taylor, Peter ; Mendelsohn, A. ; Baker, D. ; Kim, L. ; Ritchlin, C. ; Taylor, Peter ; Mariette, Xavier ; Matucci Cerenic, Marco ; Pavelka, Karel ; van Vollenhoven, Ronald ; Heatley, Rebecca ; Walsh, Claire ; Lawson, Richard ; Reynolds, Alan ; Emery, Paul ; Iaremenko, Oleg ; Mikitenko, Ganna ; Smolen, Josef ; van Vollenhoven, Ronald ; Kavanaugh, Arthur ; Luijtens, Kristel ; van der Heijde, Désirée ; Curtis, Jeffrey ; van der Heijde, Désirée ; Schiff, Michael ; Keystone, Edward ; Landewe, Robert ; Kvien, Tore ; Curtis, Jeffrey ; Khanna, Dinesh ; Luijtens, Kristel ; Furst, Dan ; Behrens, Frank ; Koehm, Michaela ; Scharbatke, Eva C. ; Kleinert, Stefan ; Weyer, Gerd ; Tony, Hans-Peter ; Burkhardt, Harald ; Blunn, Karina J. ; Williams, Richard B. ; Young, Adam ; McDowell, Jackie ; Keystone, Edward ; Weinblatt, Michael ; Haraoui, Boulos ; Guérette, Benoit ; Mozaffarian, Neelufar ; Patra, Kaushik ; Kavanaugh, Arthur ; Khraishi, Majed ; Alten, Rieke ; Gomez-Reino, Juan ; Rizzo, Warren ; Schechtman, Joy ; Kahan, Andre ; Vernon, Emma ; Taylor, Monet ; Smolen, Josef ; Hogan, Vanessa ; Holweg, Cecile ; Kummerfeld, Sarah ; Teng, Onno ; Townsend, Michael ; van Laar, Jacob M. ; Gullick, Nicola J. ; De Silva, Chulanie ; Kirkham, Bruce W. ; van der Heijde, Désirée ; Landewe, Robert ; Guérette, Benoit ; Roy, Sanjoy ; Patra, Kaushik ; Keystone, Edward ; Emery, P. ; Fleischmann, R. ; van der Heijde, D. ; Keystone, E. ; Genovese, M. C. ; Conaghan, P. G. ; Hsia, E. C. ; Xu, W. ; Baratelle, A. ; Beutler, A. ; Rahman, M. U. ; Nikiphorou, Elena ; Kiely, Patrick ; Walsh, David A. ; Williams, Richard ; Young, Adam ; Shah, Devron ; Knight, Gregory D. ; Hutchinson, David G. ; Dass, Shouvik ; Atzeni, Fabiola ; Vital, Edward M. ; Bingham, Sarah J. ; Buch, Maya ; Beirne, Paul ; Emery, Paul ; Keystone, Edward ; Fleischmann, Roy ; Emery, Paul ; Dougados, Maxime ; Williams, Sarah ; Reynard, Mark ; Blackler, Laura ; Gullick, Nicola J. ; Zain, Amir ; Oakley, Stephen ; Rees, Jonathon ; Jones, Tim ; Mistlin, Alan ; Panayi, Gabriel ; Kirkham, Bruce W. ; Westhovens, Rene ; Durez, Patrick ; Genant, Harry ; Robles, Manuel ; Becker, Jean-Claude ; Covucci, Allison ; Bathon, Joan ; Genovese, Mark C. ; Schiff, Michael ; Luggen, Michael ; Le Bars, Manuela ; Becker, Jean-Claude ; Aranda, Richard ; Li, Tracy ; Elegbe, Ayanbola ; Dougados, Maxime ; Smolen, Josef ; van Vollenhoven, Ronald ; Kavanaugh, Arthur ; Fichtner, Andreas ; Strand, Vibeke ; Vencovsky, Jiri ; van der Heijde, Désirée ; Davies, Rebecca ; Galloway, James ; Watson, Kath D. ; Lunt, Mark ; Hochberg, Marc ; Westhovens, Rene ; Aranda, Richard ; Kelly, Sheila ; Khan, Nadar ; Qi, Keqin ; Pappu, Ramesh ; Delaet, Ingrid ; Luo, Allison ; Torbeyns, Anne ; Moreland, Larry ; Cohen, Roger ; Gujrathi, Sheila ; Weinblatt, Michael ; Bykerk, Vivian P. ; Álvaro-Gracia, Jose ; Andres Roman Ivorra, Jose ; Nurmohamed, Michael T. ; Pavelka, Karel ; Bernasconi, Corrado ; Stancati, Andrea ; Sibilia, Jean ; Östör, Andrew ; Strangfeld, Anja ; Eveslage, Maria ; Listing, Joachim ; Herzer, Peter ; Liebhaber, Anke ; Krummel-Lorenz, Brigitte ; Zink, Angela ; Haraoui, Boulos ; Emery, Paul ; Mozaffarian, Neelufar ; Guérette, Benoit ; Kupper, Hartmut ; Patra, Kaushik ; Keystone, Edward ; Genovese, Mark C. ; Breedveld, Ferdinand C. ; Emery, Paul ; Cohen, Stanley B. ; Keystone, Edward ; Matteson, Eric L. ; Burke, Laura ; Chai, Akiko ; Reiss, William ; Sweetser, Marianne ; Shaw, Tim ; Ellis, Shawn D. ; Ehrenstein, Michael R. ; Notley, Clare A. ; Yazici, Yusuf ; Curtis, Jeffrey ; Ince, Akgun ; Baraf, Herbert ; Malamet, Raymond ; Chung, Carol Y. ; Kavanaugh, Arthur ; Hughes, Chris ; Faurholm, Bjarne ; Dell'Accio, Francesco ; Manzo, Antonio ; Seed, Michael ; Eltawil, Noha ; Marrelli, Alessandra ; Gould, David ; Subang, Christina ; Al-Kashi, Adam ; De Bari, Cosimo ; Winyard, Paul ; Chernajovsky, Yuti ; Nissim, Ahuva ; van Vollenhoven, Ronald ; Emery, Paul ; Bingham, Clifton ; Keystone, Edward ; Fleischmann, Roy M. ; Furst, Daniel E. ; Macey, Katherine M. ; Sweetser, Marianne T. ; Lehane, Patricia ; Farmer, Pamela ; Long, Simon G. ; Kremer, Joel M. ; Furst, Daniel E. ; Burgos-Vargas, Ruben ; Dudler, Jean ; Mela, Christopher M. ; Vernon, Emma ; Fleischmann, Roy M. ; Wegner, Natalia ; Lugli, Helena ; Quirke, Anne-Marie ; Guo, Yonghua ; Potempa, Jan ; Venables, Patrick

In: Rheumatology, 2011, vol. 50, p. iii111-iii129

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    Title
    • Rheumatoid arthritis - treatment
      180. Utility of Body Weight Classified Low-Dose Leflunomide in Japanese Rheumatoid Arthritis
    Author
    • Nishikawa, Masataka. Orthopaedic Surgery, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan; Rheumatology, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan
    • Owaki, Hajime. Orthopaedic Surgery, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan; Rheumatology, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan
    • Fuji, Takeshi. Orthopaedic Surgery, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan; Rheumatology, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan
    • Soliman, Moetaza M.. School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Ashcroft, Darren M.. School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Watson, Kath D.. School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Lunt, Mark. School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Symmons, Deborah. School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Hyrich, Kimme L.. School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, United Kingdom; Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    • Atkinson, Francesca. Rheumatology, QEH Gateshead, Gateshead, United Kingdom
    • Malik, Saadia. Rheumatology, QEH Gateshead, Gateshead, United Kingdom
    • Heycock, Carol. Rheumatology, QEH Gateshead, Gateshead, United Kingdom
    • Saravanan, Vadivelu. Rheumatology, QEH Gateshead, Gateshead, United Kingdom
    • Rynne, Martin. Rheumatology, QEH Gateshead, Gateshead, United Kingdom
    • Hamilton, Jennifer. Rheumatology, QEH Gateshead, Gateshead, United Kingdom
    • Kelly, Clive. Rheumatology, QEH Gateshead, Gateshead, United Kingdom
    • Burmester, Gerd. University Medicine, Charité, Berlin, Germany; Abbott, Abbott GmbH & Co. KG, Ludwigshafen, Germany; Abbott France, Abbott, Rungis, France
    • Kary, Sonja. University Medicine, Charité, Berlin, Germany; Abbott, Abbott GmbH & Co. KG, Ludwigshafen, Germany; Abbott France, Abbott, Rungis, France
    • Unnebrink, Kristina. University Medicine, Charité, Berlin, Germany; Abbott, Abbott GmbH & Co. KG, Ludwigshafen, Germany; Abbott France, Abbott, Rungis, France
    • Guérette, Benoit. University Medicine, Charité, Berlin, Germany; Abbott, Abbott GmbH & Co. KG, Ludwigshafen, Germany; Abbott France, Abbott, Rungis, France
    • Oezer, Uemit. University Medicine, Charité, Berlin, Germany; Abbott, Abbott GmbH & Co. KG, Ludwigshafen, Germany; Abbott France, Abbott, Rungis, France
    • Kupper, Hartmut. University Medicine, Charité, Berlin, Germany; Abbott, Abbott GmbH & Co. KG, Ludwigshafen, Germany; Abbott France, Abbott, Rungis, France
    • Dennison, Elaine. MRC Lifecourse Epidemiology Unit, Southampton University, Southampton, United Kingdom; Arthritis Research UK Epidemiology Unit, Manchester University, Manchester, United Kingdom
    • Jameson, Karen. MRC Lifecourse Epidemiology Unit, Southampton University, Southampton, United Kingdom; Arthritis Research UK Epidemiology Unit, Manchester University, Manchester, United Kingdom
    • Hyrich, Kimme. MRC Lifecourse Epidemiology Unit, Southampton University, Southampton, United Kingdom; Arthritis Research UK Epidemiology Unit, Manchester University, Manchester, United Kingdom
    • Watson, Kath. MRC Lifecourse Epidemiology Unit, Southampton University, Southampton, United Kingdom; Arthritis Research UK Epidemiology Unit, Manchester University, Manchester, United Kingdom
    • Landewe, Robert. Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Rheumatology, Medical University of Vienna, Vienna, Austria; Department of Cell & Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Keystone, Edward. Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Rheumatology, Medical University of Vienna, Vienna, Austria; Department of Cell & Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Smolen, Josef. Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Rheumatology, Medical University of Vienna, Vienna, Austria; Department of Cell & Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Goldring, Mary. Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Rheumatology, Medical University of Vienna, Vienna, Austria; Department of Cell & Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Guérette, Benoit. Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Rheumatology, Medical University of Vienna, Vienna, Austria; Department of Cell & Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Patra, Kaushik. Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Rheumatology, Medical University of Vienna, Vienna, Austria; Department of Cell & Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Cifaldi, Mary. Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Rheumatology, Medical University of Vienna, Vienna, Austria; Department of Cell & Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • van der Heijde, Désirée. Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Rheumatology, Medical University of Vienna, Vienna, Austria; Department of Cell & Developmental Biology, Weill Cornell Medical College, New York, NY, USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Lloyd, Lois A.. Department of Rheumatology, Betsi Cadwaladr University Healthboard, Bangor, United Kingdom; Department of Pharmacy, Betsi Cadwaladr University Healthboard, Bangor, United Kingdom
    • Owen, Catherine. Department of Rheumatology, Betsi Cadwaladr University Healthboard, Bangor, United Kingdom; Department of Pharmacy, Betsi Cadwaladr University Healthboard, Bangor, United Kingdom
    • Breslin, Anne. Department of Rheumatology, Betsi Cadwaladr University Healthboard, Bangor, United Kingdom; Department of Pharmacy, Betsi Cadwaladr University Healthboard, Bangor, United Kingdom
    • Ahmad, Yasmeen. Department of Rheumatology, Betsi Cadwaladr University Healthboard, Bangor, United Kingdom; Department of Pharmacy, Betsi Cadwaladr University Healthboard, Bangor, United Kingdom
    • Emery, Paul. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, Mayo Clinic, Rochester, MN, USA; Medicine, Stanford University, Palo Alto, CA, USA; Clinical Research, Centocor Research & Development, Inc., Malvern, PA, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA; Elashoff Consulting, Redwood City, CA, USA
    • Matteson, E. L.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, Mayo Clinic, Rochester, MN, USA; Medicine, Stanford University, Palo Alto, CA, USA; Clinical Research, Centocor Research & Development, Inc., Malvern, PA, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA; Elashoff Consulting, Redwood City, CA, USA
    • Genovese, M.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, Mayo Clinic, Rochester, MN, USA; Medicine, Stanford University, Palo Alto, CA, USA; Clinical Research, Centocor Research & Development, Inc., Malvern, PA, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA; Elashoff Consulting, Redwood City, CA, USA
    • Sague, S.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, Mayo Clinic, Rochester, MN, USA; Medicine, Stanford University, Palo Alto, CA, USA; Clinical Research, Centocor Research & Development, Inc., Malvern, PA, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA; Elashoff Consulting, Redwood City, CA, USA
    • Hsia, E. C.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, Mayo Clinic, Rochester, MN, USA; Medicine, Stanford University, Palo Alto, CA, USA; Clinical Research, Centocor Research & Development, Inc., Malvern, PA, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA; Elashoff Consulting, Redwood City, CA, USA
    • Doyle, M. K.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, Mayo Clinic, Rochester, MN, USA; Medicine, Stanford University, Palo Alto, CA, USA; Clinical Research, Centocor Research & Development, Inc., Malvern, PA, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA; Elashoff Consulting, Redwood City, CA, USA
    • Fan, H.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, Mayo Clinic, Rochester, MN, USA; Medicine, Stanford University, Palo Alto, CA, USA; Clinical Research, Centocor Research & Development, Inc., Malvern, PA, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA; Elashoff Consulting, Redwood City, CA, USA
    • Elashoff, M.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, Mayo Clinic, Rochester, MN, USA; Medicine, Stanford University, Palo Alto, CA, USA; Clinical Research, Centocor Research & Development, Inc., Malvern, PA, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA; Elashoff Consulting, Redwood City, CA, USA
    • Kirkham, Bruce. Rheumatology, Guy's and St. Thomas' Hospital, London, United Kingdom; Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Medicine, Stanford University, Palo Alto, CA, USA; Rheumatology, Mayo Clinic, Rochester, MN, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Wasco, M. C.. Rheumatology, Guy's and St. Thomas' Hospital, London, United Kingdom; Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Medicine, Stanford University, Palo Alto, CA, USA; Rheumatology, Mayo Clinic, Rochester, MN, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Bathon, J.. Rheumatology, Guy's and St. Thomas' Hospital, London, United Kingdom; Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Medicine, Stanford University, Palo Alto, CA, USA; Rheumatology, Mayo Clinic, Rochester, MN, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Hsia, E. C.. Rheumatology, Guy's and St. Thomas' Hospital, London, United Kingdom; Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Medicine, Stanford University, Palo Alto, CA, USA; Rheumatology, Mayo Clinic, Rochester, MN, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Fleischmann, R.. Rheumatology, Guy's and St. Thomas' Hospital, London, United Kingdom; Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Medicine, Stanford University, Palo Alto, CA, USA; Rheumatology, Mayo Clinic, Rochester, MN, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Genovese, M. C.. Rheumatology, Guy's and St. Thomas' Hospital, London, United Kingdom; Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Medicine, Stanford University, Palo Alto, CA, USA; Rheumatology, Mayo Clinic, Rochester, MN, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Matteson, E. L.. Rheumatology, Guy's and St. Thomas' Hospital, London, United Kingdom; Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Medicine, Stanford University, Palo Alto, CA, USA; Rheumatology, Mayo Clinic, Rochester, MN, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Liu, H.. Rheumatology, Guy's and St. Thomas' Hospital, London, United Kingdom; Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Medicine, Stanford University, Palo Alto, CA, USA; Rheumatology, Mayo Clinic, Rochester, MN, USA; Bioinformatics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Fleischmann, R.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Goldman, J.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Leirisalo-Repo, M.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Zanetakis, E.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • El-Kadi, H.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Kellner, H.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Bolce, R.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Wang, J.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Dehoratius, R.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Decktor, D.. Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Atlanta Center for Clinical Research, Atlanta, GA, USA; Rheumatology, Helsinki University Central Hospital, Helsinki, Finland; Rheumatology, Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa, OK, USA; Rheumatology, Arthritis & Osteoporosis Associates, P.A., Freehold, NJ, USA; Rheumatology, Center for Inflammatory Joint Diseases, Romanstrasse/Muenchen, Germany; Medical Affairs, Centocor Ortho Biotech Services, LLC, Horsham, PA, USA; Clinical Research, Johnson & Johnson Pharmaceutical Research and Development, LLC, Belle Mead, NJ, USA
    • Kremer, J.. Rheumatology, Albany Medical Center, Albany, NY, USA; Medicine, Imperial College of London, London, United Kingdom; Immunology, Centocor Research and Development, Inc., Malvern, PA; Rheumatology, University of Rochester, Rochester, NY, USA
    • Taylor, Peter. Rheumatology, Albany Medical Center, Albany, NY, USA; Medicine, Imperial College of London, London, United Kingdom; Immunology, Centocor Research and Development, Inc., Malvern, PA; Rheumatology, University of Rochester, Rochester, NY, USA
    • Mendelsohn, A.. Rheumatology, Albany Medical Center, Albany, NY, USA; Medicine, Imperial College of London, London, United Kingdom; Immunology, Centocor Research and Development, Inc., Malvern, PA; Rheumatology, University of Rochester, Rochester, NY, USA
    • Baker, D.. Rheumatology, Albany Medical Center, Albany, NY, USA; Medicine, Imperial College of London, London, United Kingdom; Immunology, Centocor Research and Development, Inc., Malvern, PA; Rheumatology, University of Rochester, Rochester, NY, USA
    • Kim, L.. Rheumatology, Albany Medical Center, Albany, NY, USA; Medicine, Imperial College of London, London, United Kingdom; Immunology, Centocor Research and Development, Inc., Malvern, PA; Rheumatology, University of Rochester, Rochester, NY, USA
    • Ritchlin, C.. Orthopaedic Surgery, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan; 2Rheumatology, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan
    • Taylor, Peter. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Mariette, Xavier. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Matucci Cerenic, Marco. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Pavelka, Karel. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • van Vollenhoven, Ronald. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Heatley, Rebecca. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Walsh, Claire. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Lawson, Richard. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Reynolds, Alan. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Emery, Paul. Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, United Kingdom; Hôpital Bicêtre, Université Paris-Sud 11, Paris, France; Institut Pour la Santé et la Recherche Médicale, INSERM 1012, Paris, France; Department of Biomedicine, University of Florence, Florence, Italy; Institute of Rheumatology, Charles University, Prague, Czech Republic; Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Stockholm, Sweden; Complete Market Access, Complete Medical Group, Macclesfield, United Kingdom; Reynolds Clinical Sciences Ltd, Eastleigh, United Kingdom; Institute of Molecular Medicine, Leeds University, Leeds, United Kingdom
    • Iaremenko, Oleg. Internal Medicine N2, National Medical University O.O.Bogomolets, Kyiv, Ukraine
    • Mikitenko, Ganna. Internal Medicine N2, National Medical University O.O.Bogomolets, Kyiv, Ukraine
    • Smolen, Josef. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Brussels, Belgium; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
    • van Vollenhoven, Ronald. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Brussels, Belgium; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
    • Kavanaugh, Arthur. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Brussels, Belgium; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
    • Luijtens, Kristel. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Brussels, Belgium; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
    • van der Heijde, Désirée. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Brussels, Belgium; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
    • Curtis, Jeffrey. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Brussels, Belgium; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
    • van der Heijde, Désirée. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Schiff, Michael. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Keystone, Edward. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Landewe, Robert. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Kvien, Tore. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Curtis, Jeffrey. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Khanna, Dinesh. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Luijtens, Kristel. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Furst, Dan. Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatology Division, University of Colorado School of Medicine, Denver, CO, USA; Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada; Department of Internal Medicine/Rheumatology, Maastricht University Medical, Maastricht, Netherlands; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA; Rheumatology & Arthritis, UCLA, Los Angeles, CA; Global Biostatistics, UCB, Brussels, Belgium
    • Behrens, Frank. Rheumatology, J.W. Goethe-University, Frankfurt, Germany; Rheumatology, University of Würzburg, Würzburg, Germany; Biostatistics, ICRC, Berlin, Germany
    • Koehm, Michaela. Rheumatology, J.W. Goethe-University, Frankfurt, Germany; Rheumatology, University of Würzburg, Würzburg, Germany; Biostatistics, ICRC, Berlin, Germany
    • Scharbatke, Eva C.. Rheumatology, J.W. Goethe-University, Frankfurt, Germany; Rheumatology, University of Würzburg, Würzburg, Germany; Biostatistics, ICRC, Berlin, Germany
    • Kleinert, Stefan. Rheumatology, J.W. Goethe-University, Frankfurt, Germany; Rheumatology, University of Würzburg, Würzburg, Germany; Biostatistics, ICRC, Berlin, Germany
    • Weyer, Gerd. Rheumatology, J.W. Goethe-University, Frankfurt, Germany; Rheumatology, University of Würzburg, Würzburg, Germany; Biostatistics, ICRC, Berlin, Germany
    • Tony, Hans-Peter. Rheumatology, J.W. Goethe-University, Frankfurt, Germany; Rheumatology, University of Würzburg, Würzburg, Germany; Biostatistics, ICRC, Berlin, Germany
    • Burkhardt, Harald. Rheumatology, J.W. Goethe-University, Frankfurt, Germany; Rheumatology, University of Würzburg, Würzburg, Germany; Biostatistics, ICRC, Berlin, Germany
    • Blunn, Karina J.. Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom; Rheumatology, St Albans NHS Trust, Herts, United Kingdom
    • Williams, Richard B.. Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom; Rheumatology, St Albans NHS Trust, Herts, United Kingdom
    • Young, Adam. Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom; Rheumatology, St Albans NHS Trust, Herts, United Kingdom
    • McDowell, Jackie. Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom; Rheumatology, St Albans NHS Trust, Herts, United Kingdom
    • Keystone, Edward. The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Medicine: Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, San Diego, CA, USA
    • Weinblatt, Michael. The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Medicine: Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, San Diego, CA, USA
    • Haraoui, Boulos. The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Medicine: Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, San Diego, CA, USA
    • Guérette, Benoit. The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Medicine: Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, San Diego, CA, USA
    • Mozaffarian, Neelufar. The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Medicine: Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, San Diego, CA, USA
    • Patra, Kaushik. The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Medicine: Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, San Diego, CA, USA
    • Kavanaugh, Arthur. The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Medicine: Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA; Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, San Diego, CA, USA
    • Khraishi, Majed. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Alten, Rieke. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Gomez-Reino, Juan. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Rizzo, Warren. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Schechtman, Joy. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Kahan, Andre. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Vernon, Emma. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Taylor, Monet. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Smolen, Josef. Rheumatology, Memorial University of Newfoundland, St Johns, Canada; Rheumatology, University of Berlin, Berlin, Germany; Rheumatology, Hospital Clínico U. de Santiago, Santiago, Spain; Rheumatology, Advance Arthritis care, Scottsdale, AZ, USA; Rheumatology, Sun Valley Arthritis Center, Peoria, AZ, USA; Rheumatology, Paris Descartes University, Paris, France; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, University Clinic for Internal Medicine, Vienna, Austria
    • Hogan, Vanessa. Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, United Kingdom; gRED Biomarker Group, Genentech, Palo Alto, CA, USA; Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
    • Holweg, Cecile. Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, United Kingdom; gRED Biomarker Group, Genentech, Palo Alto, CA, USA; Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
    • Kummerfeld, Sarah. Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, United Kingdom; gRED Biomarker Group, Genentech, Palo Alto, CA, USA; Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
    • Teng, Onno. Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, United Kingdom; gRED Biomarker Group, Genentech, Palo Alto, CA, USA; Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
    • Townsend, Michael. Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, United Kingdom; gRED Biomarker Group, Genentech, Palo Alto, CA, USA; Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
    • van Laar, Jacob M.. Musculoskeletal Research Group, Newcastle University, Newcastle Upon Tyne, United Kingdom; gRED Biomarker Group, Genentech, Palo Alto, CA, USA; Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
    • Gullick, Nicola J.. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; NIHR Comprehensive Biomedical Research Centre, Guy's & St Thomas' Hospitals & King's College London, London, United Kingdom
    • De Silva, Chulanie. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; NIHR Comprehensive Biomedical Research Centre, Guy's & St Thomas' Hospitals & King's College London, London, United Kingdom
    • Kirkham, Bruce W.. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; NIHR Comprehensive Biomedical Research Centre, Guy's & St Thomas' Hospitals & King's College London, London, United Kingdom
    • van der Heijde, Désirée. Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Landewe, Robert. Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Guérette, Benoit. Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Roy, Sanjoy. Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Patra, Kaushik. Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Keystone, Edward. Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, Netherlands; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL, USA; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Emery, P.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Fleischmann, R.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • van der Heijde, D.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Keystone, E.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Genovese, M. C.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Conaghan, P. G.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Hsia, E. C.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Xu, W.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Baratelle, A.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Beutler, A.. Rheumatology, University of Leeds, Leeds, United Kingdom; Rheumatology, University of Texas/SW Medical Center, Dallas, TX, USA; Rheumatology, Leiden University Medical Center, Leiden, Netherlands; Rheumatic & Immunologic Diseases, University of Toronto and Mt Sinai Hospital, Toronto, ON, Canada; Medicine, Stanford University, Palo Alto, CA,USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Immunology, Centocor Research & Development, Inc., Malvern, PA, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Biostatistics, Centocor Research & Development, Inc., Malvern, PA, USA
    • Rahman, M. U.. Orthopaedic Surgery, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan; 2Rheumatology, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan
    • Nikiphorou, Elena. Department of Rheumatology, ERAN, c/o St Albans City Hospital, St Albans, United Kingdom; Department of Rheumatology, St George's Healthcare NHS Trust, London, United Kingdom; Department of Rheumatology, Sherwood Forest Hospitals NHS Trust/University of Nottingham, Nottingham, United Kingdom; Department of Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom
    • Kiely, Patrick. Department of Rheumatology, ERAN, c/o St Albans City Hospital, St Albans, United Kingdom; Department of Rheumatology, St George's Healthcare NHS Trust, London, United Kingdom; Department of Rheumatology, Sherwood Forest Hospitals NHS Trust/University of Nottingham, Nottingham, United Kingdom; Department of Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom
    • Walsh, David A.. Department of Rheumatology, ERAN, c/o St Albans City Hospital, St Albans, United Kingdom; Department of Rheumatology, St George's Healthcare NHS Trust, London, United Kingdom; Department of Rheumatology, Sherwood Forest Hospitals NHS Trust/University of Nottingham, Nottingham, United Kingdom; Department of Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom
    • Williams, Richard. Department of Rheumatology, ERAN, c/o St Albans City Hospital, St Albans, United Kingdom; Department of Rheumatology, St George's Healthcare NHS Trust, London, United Kingdom; Department of Rheumatology, Sherwood Forest Hospitals NHS Trust/University of Nottingham, Nottingham, United Kingdom; Department of Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom
    • Young, Adam. Department of Rheumatology, ERAN, c/o St Albans City Hospital, St Albans, United Kingdom; Department of Rheumatology, St George's Healthcare NHS Trust, London, United Kingdom; Department of Rheumatology, Sherwood Forest Hospitals NHS Trust/University of Nottingham, Nottingham, United Kingdom; Department of Rheumatology, Hereford Hospitals NHS Trust, Hereford, United Kingdom
    • Shah, Devron. Knowledge Spa, Peninsula Medical School, Truro, United Kingdom; Rheumatology Department, Royal Cornwall Hospital, Truro, United Kingdom
    • Knight, Gregory D.. Knowledge Spa, Peninsula Medical School, Truro, United Kingdom; Rheumatology Department, Royal Cornwall Hospital, Truro, United Kingdom
    • Hutchinson, David G.. Knowledge Spa, Peninsula Medical School, Truro, United Kingdom; Rheumatology Department, Royal Cornwall Hospital, Truro, United Kingdom
    • Dass, Shouvik. Academic Section of Musculoskeletal Disease, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    • Atzeni, Fabiola. Academic Section of Musculoskeletal Disease, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    • Vital, Edward M.. Academic Section of Musculoskeletal Disease, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    • Bingham, Sarah J.. Academic Section of Musculoskeletal Disease, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    • Buch, Maya. Academic Section of Musculoskeletal Disease, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    • Beirne, Paul. Academic Section of Musculoskeletal Disease, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    • Emery, Paul. Academic Section of Musculoskeletal Disease, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    • Keystone, Edward. Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Hôpital Cochin, Paris, France; PDBB, Roche Products Ltd, Welwyn Garden City, United Kingdom
    • Fleischmann, Roy. Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Hôpital Cochin, Paris, France; PDBB, Roche Products Ltd, Welwyn Garden City, United Kingdom
    • Emery, Paul. Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Hôpital Cochin, Paris, France; PDBB, Roche Products Ltd, Welwyn Garden City, United Kingdom
    • Dougados, Maxime. Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Hôpital Cochin, Paris, France; PDBB, Roche Products Ltd, Welwyn Garden City, United Kingdom
    • Williams, Sarah. Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Hôpital Cochin, Paris, France; PDBB, Roche Products Ltd, Welwyn Garden City, United Kingdom
    • Reynard, Mark. Rheumatology, University of Toronto, Toronto, ON, Canada; Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Hôpital Cochin, Paris, France; PDBB, Roche Products Ltd, Welwyn Garden City, United Kingdom
    • Blackler, Laura. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Gullick, Nicola J.. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Zain, Amir. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Oakley, Stephen. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Rees, Jonathon. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Jones, Tim. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Mistlin, Alan. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Panayi, Gabriel. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Kirkham, Bruce W.. Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom; Rheumatology, King's College London, London, United Kingdom; Rheumatology, Royal Newcastle Centre, Newcastle, NSW, Australia; Rheumatology, DMRC Headley Court, Epsom, United Kingdom
    • Westhovens, Rene. Department of Rheumatology, UZ Gasthuisberg, Leuven, Belgium; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Department of Rheumatology, University of California, San Francisco, CA, USA; Rheumatology Department, Centro Médico Toluca, Metepec, Mexico; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, MD, USA
    • Durez, Patrick. Department of Rheumatology, UZ Gasthuisberg, Leuven, Belgium; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Department of Rheumatology, University of California, San Francisco, CA, USA; Rheumatology Department, Centro Médico Toluca, Metepec, Mexico; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, MD, USA
    • Genant, Harry. Department of Rheumatology, UZ Gasthuisberg, Leuven, Belgium; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Department of Rheumatology, University of California, San Francisco, CA, USA; Rheumatology Department, Centro Médico Toluca, Metepec, Mexico; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, MD, USA
    • Robles, Manuel. Department of Rheumatology, UZ Gasthuisberg, Leuven, Belgium; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Department of Rheumatology, University of California, San Francisco, CA, USA; Rheumatology Department, Centro Médico Toluca, Metepec, Mexico; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, MD, USA
    • Becker, Jean-Claude. Department of Rheumatology, UZ Gasthuisberg, Leuven, Belgium; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Department of Rheumatology, University of California, San Francisco, CA, USA; Rheumatology Department, Centro Médico Toluca, Metepec, Mexico; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, MD, USA
    • Covucci, Allison. Department of Rheumatology, UZ Gasthuisberg, Leuven, Belgium; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Department of Rheumatology, University of California, San Francisco, CA, USA; Rheumatology Department, Centro Médico Toluca, Metepec, Mexico; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, MD, USA
    • Bathon, Joan. Department of Rheumatology, UZ Gasthuisberg, Leuven, Belgium; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Department of Rheumatology, University of California, San Francisco, CA, USA; Rheumatology Department, Centro Médico Toluca, Metepec, Mexico; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, MD, USA
    • Genovese, Mark C.. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Schiff, Michael. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Luggen, Michael. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Le Bars, Manuela. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Becker, Jean-Claude. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Aranda, Richard. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Li, Tracy. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Elegbe, Ayanbola. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Dougados, Maxime. Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA,USA; Rheumatology Division, University of Colorado, Denver, CO, USA; Rheumatology Department, University of Cincinnati Medical Center, Cincinnati, OH, USA; Bristol-Myers Squibb, Bristol-Myers Squibb, Rueil-Malmaison, France; Bristol-Myers Squibb, Bristol-Myers Squibb, Princeton, NJ, USA; Rheumatology Department, Hospital Cochin, Paris, France
    • Smolen, Josef. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Monheim, Germany; Department of Medicine, Stanford University, Palo Alto, CA, USA; Medicine, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • van Vollenhoven, Ronald. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Monheim, Germany; Department of Medicine, Stanford University, Palo Alto, CA, USA; Medicine, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Kavanaugh, Arthur. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Monheim, Germany; Department of Medicine, Stanford University, Palo Alto, CA, USA; Medicine, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Fichtner, Andreas. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Monheim, Germany; Department of Medicine, Stanford University, Palo Alto, CA, USA; Medicine, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Strand, Vibeke. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Monheim, Germany; Department of Medicine, Stanford University, Palo Alto, CA, USA; Medicine, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Vencovsky, Jiri. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Monheim, Germany; Department of Medicine, Stanford University, Palo Alto, CA, USA; Medicine, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • van der Heijde, Désirée. Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria; Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Rheumatology Division, UCSD, San Diego, CA, USA; Global Biostatistics, UCB, Monheim, Germany; Department of Medicine, Stanford University, Palo Alto, CA, USA; Medicine, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Leiden University Medical Center, Leiden, Netherlands
    • Davies, Rebecca. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    • Galloway, James. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    • Watson, Kath D.. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    • Lunt, Mark. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    • Hochberg, Marc. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Westhovens, Rene. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Aranda, Richard. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Kelly, Sheila. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Khan, Nadar. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Qi, Keqin. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Pappu, Ramesh. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Delaet, Ingrid. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Luo, Allison. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Torbeyns, Anne. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Moreland, Larry. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Cohen, Roger. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Gujrathi, Sheila. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Weinblatt, Michael. Department of Medicine, Division of Rheumatology, Baltimore, MD, USA; Department of Rheumatology, Catholic University of Leuven, Leuven, Belgium; Bristol-Myers Squibb, Princeton, NJ, USA; Bristol-Myers Squibb, Braine-l'Alleud, Belgium; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA,USA; Fox Chase Cancer Center, Philadelphia, PA, USA; Department of Rheumatology and Immunology, Brigham & Women's Hospital, Boston, MA, USA
    • Bykerk, Vivian P.. Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain; Rheumatology, Hospital Universitario Dr. Peset, Valencia, Spain; Rheumatology, Jan van Breemen Institute, Amsterdam, Netherlands; Rheumatology, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Roche, Basel, Switzerland; Rheumatology, Hautepierre Service de Rhumatologie, Strasbourg, France; Rheumatology, Addenbrookes Hospital, Cambridge, United Kingdom
    • Álvaro-Gracia, Jose. Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain; Rheumatology, Hospital Universitario Dr. Peset, Valencia, Spain; Rheumatology, Jan van Breemen Institute, Amsterdam, Netherlands; Rheumatology, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Roche, Basel, Switzerland; Rheumatology, Hautepierre Service de Rhumatologie, Strasbourg, France; Rheumatology, Addenbrookes Hospital, Cambridge, United Kingdom
    • Andres Roman Ivorra, Jose. Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain; Rheumatology, Hospital Universitario Dr. Peset, Valencia, Spain; Rheumatology, Jan van Breemen Institute, Amsterdam, Netherlands; Rheumatology, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Roche, Basel, Switzerland; Rheumatology, Hautepierre Service de Rhumatologie, Strasbourg, France; Rheumatology, Addenbrookes Hospital, Cambridge, United Kingdom
    • Nurmohamed, Michael T.. Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain; Rheumatology, Hospital Universitario Dr. Peset, Valencia, Spain; Rheumatology, Jan van Breemen Institute, Amsterdam, Netherlands; Rheumatology, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Roche, Basel, Switzerland; Rheumatology, Hautepierre Service de Rhumatologie, Strasbourg, France; Rheumatology, Addenbrookes Hospital, Cambridge, United Kingdom
    • Pavelka, Karel. Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain; Rheumatology, Hospital Universitario Dr. Peset, Valencia, Spain; Rheumatology, Jan van Breemen Institute, Amsterdam, Netherlands; Rheumatology, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Roche, Basel, Switzerland; Rheumatology, Hautepierre Service de Rhumatologie, Strasbourg, France; Rheumatology, Addenbrookes Hospital, Cambridge, United Kingdom
    • Bernasconi, Corrado. Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain; Rheumatology, Hospital Universitario Dr. Peset, Valencia, Spain; Rheumatology, Jan van Breemen Institute, Amsterdam, Netherlands; Rheumatology, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Roche, Basel, Switzerland; Rheumatology, Hautepierre Service de Rhumatologie, Strasbourg, France; Rheumatology, Addenbrookes Hospital, Cambridge, United Kingdom
    • Stancati, Andrea. Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain; Rheumatology, Hospital Universitario Dr. Peset, Valencia, Spain; Rheumatology, Jan van Breemen Institute, Amsterdam, Netherlands; Rheumatology, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Roche, Basel, Switzerland; Rheumatology, Hautepierre Service de Rhumatologie, Strasbourg, France; Rheumatology, Addenbrookes Hospital, Cambridge, United Kingdom
    • Sibilia, Jean. Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain; Rheumatology, Hospital Universitario Dr. Peset, Valencia, Spain; Rheumatology, Jan van Breemen Institute, Amsterdam, Netherlands; Rheumatology, Institute of Rheumatology, Prague, Czech Republic; Rheumatology, Roche, Basel, Switzerland; Rheumatology, Hautepierre Service de Rhumatologie, Strasbourg, France; Rheumatology, Addenbrookes Hospital, Cambridge, United Kingdom
    • Östör, Andrew. Orthopaedic Surgery, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan; 2Rheumatology, Osaka Koseinenkin Hospital, Osaka City, Osaka, Japan
    • Strangfeld, Anja. Epidemiology Unit, Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany; Scientific Advisory Board, München, Germany; Private practice, Halle/S, Germany; Private practice, Frankfurt/M, Germany; Rheumatology and clinical Immunology, Charité University Hospital, Berlin, Germany
    • Eveslage, Maria. Epidemiology Unit, Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany; Scientific Advisory Board, München, Germany; Private practice, Halle/S, Germany; Private practice, Frankfurt/M, Germany; Rheumatology and clinical Immunology, Charité University Hospital, Berlin, Germany
    • Listing, Joachim. Epidemiology Unit, Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany; Scientific Advisory Board, München, Germany; Private practice, Halle/S, Germany; Private practice, Frankfurt/M, Germany; Rheumatology and clinical Immunology, Charité University Hospital, Berlin, Germany
    • Herzer, Peter. Epidemiology Unit, Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany; Scientific Advisory Board, München, Germany; Private practice, Halle/S, Germany; Private practice, Frankfurt/M, Germany; Rheumatology and clinical Immunology, Charité University Hospital, Berlin, Germany
    • Liebhaber, Anke. Epidemiology Unit, Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany; Scientific Advisory Board, München, Germany; Private practice, Halle/S, Germany; Private practice, Frankfurt/M, Germany; Rheumatology and clinical Immunology, Charité University Hospital, Berlin, Germany
    • Krummel-Lorenz, Brigitte. Epidemiology Unit, Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany; Scientific Advisory Board, München, Germany; Private practice, Halle/S, Germany; Private practice, Frankfurt/M, Germany; Rheumatology and clinical Immunology, Charité University Hospital, Berlin, Germany
    • Zink, Angela. Epidemiology Unit, Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany; Scientific Advisory Board, München, Germany; Private practice, Halle/S, Germany; Private practice, Frankfurt/M, Germany; Rheumatology and clinical Immunology, Charité University Hospital, Berlin, Germany
    • Haraoui, Boulos. Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Academic Section of Musculoskeletal Medicine in the Institute of Molecular Medicine, Leeds Teaching Hospital, Leeds, United Kingdom; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL,USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott GmbH & Co, Ludwigshafen, Germany; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Emery, Paul. Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Academic Section of Musculoskeletal Medicine in the Institute of Molecular Medicine, Leeds Teaching Hospital, Leeds, United Kingdom; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL,USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott GmbH & Co, Ludwigshafen, Germany; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Mozaffarian, Neelufar. Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Academic Section of Musculoskeletal Medicine in the Institute of Molecular Medicine, Leeds Teaching Hospital, Leeds, United Kingdom; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL,USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott GmbH & Co, Ludwigshafen, Germany; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Guérette, Benoit. Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Academic Section of Musculoskeletal Medicine in the Institute of Molecular Medicine, Leeds Teaching Hospital, Leeds, United Kingdom; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL,USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott GmbH & Co, Ludwigshafen, Germany; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Kupper, Hartmut. Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Academic Section of Musculoskeletal Medicine in the Institute of Molecular Medicine, Leeds Teaching Hospital, Leeds, United Kingdom; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL,USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott GmbH & Co, Ludwigshafen, Germany; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Patra, Kaushik. Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Academic Section of Musculoskeletal Medicine in the Institute of Molecular Medicine, Leeds Teaching Hospital, Leeds, United Kingdom; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL,USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott GmbH & Co, Ludwigshafen, Germany; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Keystone, Edward. Medicine: Rheumatology, Centre Hospitalier de I'Université de Montréal (CHUM, Hôpital Notre-Dame), Montréal, QC, Canada; Academic Section of Musculoskeletal Medicine in the Institute of Molecular Medicine, Leeds Teaching Hospital, Leeds, United Kingdom; Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL,USA; Global Pharmaceutical Research and Development, Abbott, Rungis, France; Global Pharmaceutical Research and Development, Abbott GmbH & Co, Ludwigshafen, Germany; The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    • Genovese, Mark C.. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Breedveld, Ferdinand C.. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Emery, Paul. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Cohen, Stanley B.. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Keystone, Edward. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Matteson, Eric L.. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Burke, Laura. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Chai, Akiko. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Reiss, William. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Sweetser, Marianne. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Shaw, Tim. Immunology-Rheumatology, Stanford University, Palo Alto, CA, USA; Rheumatology, Leiden University, Leiden, Netherlands; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Rheumatology, Mayo Clinic, Rochester, MN,USA; Product development, Roche, Welwyn Garden City, United Kingdom; Statistics, Genentech, South San Francisco, CA, USA; Drug Safety, Biogen Idec, Cambridge, MA,USA
    • Ellis, Shawn D.. Medical School, UCL, London, United Kingdom; Centre for Rheumatology, UCL, London, United Kingdom
    • Ehrenstein, Michael R.. Medical School, UCL, London, United Kingdom; Centre for Rheumatology, UCL, London, United Kingdom
    • Notley, Clare A.. Medical School, UCL, London, United Kingdom; Centre for Rheumatology, UCL, London, United Kingdom
    • Yazici, Yusuf. Rheumatology, NYU Hospital for Joint Diseases, New York, NY, USA; Rheumatology & Internal Medicine, University of Alabama, Birmingham, AL, USA; Rheumatology, St Louis University School of Medicine, St Louis, MO, USA; Rheumatology, The Center for Rheumatology and Bone Research, Wheaton, MD, USA; Biotechnology, Genentech, San Francisco, CA, USA; Rheumatology, University of California at San Diego, La Jolla, CA,USA
    • Curtis, Jeffrey. Rheumatology, NYU Hospital for Joint Diseases, New York, NY, USA; Rheumatology & Internal Medicine, University of Alabama, Birmingham, AL, USA; Rheumatology, St Louis University School of Medicine, St Louis, MO, USA; Rheumatology, The Center for Rheumatology and Bone Research, Wheaton, MD, USA; Biotechnology, Genentech, San Francisco, CA, USA; Rheumatology, University of California at San Diego, La Jolla, CA,USA
    • Ince, Akgun. Rheumatology, NYU Hospital for Joint Diseases, New York, NY, USA; Rheumatology & Internal Medicine, University of Alabama, Birmingham, AL, USA; Rheumatology, St Louis University School of Medicine, St Louis, MO, USA; Rheumatology, The Center for Rheumatology and Bone Research, Wheaton, MD, USA; Biotechnology, Genentech, San Francisco, CA, USA; Rheumatology, University of California at San Diego, La Jolla, CA,USA
    • Baraf, Herbert. Rheumatology, NYU Hospital for Joint Diseases, New York, NY, USA; Rheumatology & Internal Medicine, University of Alabama, Birmingham, AL, USA; Rheumatology, St Louis University School of Medicine, St Louis, MO, USA; Rheumatology, The Center for Rheumatology and Bone Research, Wheaton, MD, USA; Biotechnology, Genentech, San Francisco, CA, USA; Rheumatology, University of California at San Diego, La Jolla, CA,USA
    • Malamet, Raymond. Rheumatology, NYU Hospital for Joint Diseases, New York, NY, USA; Rheumatology & Internal Medicine, University of Alabama, Birmingham, AL, USA; Rheumatology, St Louis University School of Medicine, St Louis, MO, USA; Rheumatology, The Center for Rheumatology and Bone Research, Wheaton, MD, USA; Biotechnology, Genentech, San Francisco, CA, USA; Rheumatology, University of California at San Diego, La Jolla, CA,USA
    • Chung, Carol Y.. Rheumatology, NYU Hospital for Joint Diseases, New York, NY, USA; Rheumatology & Internal Medicine, University of Alabama, Birmingham, AL, USA; Rheumatology, St Louis University School of Medicine, St Louis, MO, USA; Rheumatology, The Center for Rheumatology and Bone Research, Wheaton, MD, USA; Biotechnology, Genentech, San Francisco, CA, USA; Rheumatology, University of California at San Diego, La Jolla, CA,USA
    • Kavanaugh, Arthur. Rheumatology, NYU Hospital for Joint Diseases, New York, NY, USA; Rheumatology & Internal Medicine, University of Alabama, Birmingham, AL, USA; Rheumatology, St Louis University School of Medicine, St Louis, MO, USA; Rheumatology, The Center for Rheumatology and Bone Research, Wheaton, MD, USA; Biotechnology, Genentech, San Francisco, CA, USA; Rheumatology, University of California at San Diego, La Jolla, CA,USA
    • Hughes, Chris. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Faurholm, Bjarne. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Dell'Accio, Francesco. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Manzo, Antonio. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Seed, Michael. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Eltawil, Noha. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Marrelli, Alessandra. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Gould, David. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Subang, Christina. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Al-Kashi, Adam. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • De Bari, Cosimo. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Winyard, Paul. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Chernajovsky, Yuti. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • Nissim, Ahuva. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; School of Medicine & Dentistry, University of Aberdeen, Aberdeen, United Kingdom; Peninsular Medical School, University of Exeter, Exeter, United Kingdom
    • van Vollenhoven, Ronald. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Emery, Paul. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Bingham, Clifton. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Keystone, Edward. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Fleischmann, Roy M.. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Furst, Daniel E.. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Macey, Katherine M.. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Sweetser, Marianne T.. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Lehane, Patricia. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Farmer, Pamela. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Long, Simon G.. Rheumatology, Karolinska Institute, Stockholm, Sweden; Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom; Rheumatology, Johns Hopkins University, Baltimore, MD,USA; Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Medicine, University of Texas Southwestern Medical Center, Dallas, TX,USA; Rheumatology-Medicine, UCLA, Los Angeles, CA, USA; Product Development - Inflammation, Roche Products Ltd, Welwyn Garden City, United Kingdom; Drug Safety Department, Biogen Idec, Cambridge, MA, USA; Immunology Tissue Growth and Repair, Genentech, South San Francisco, CA,USA
    • Kremer, Joel M.. Rheumatology, Albany Medical College, Albany, NY, USA; Rheumatology, UCLA Medical Center, Los Angeles, CA,USA; Rheumatology, Hospital General de Mexico, Mexico City, Mexico; Rheumatology, Universidad Nacional Autónoma de México, Mexico City, Mexico; Rheumatology, Hôpital orthopédique, Lausanne, Switzerland; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA
    • Furst, Daniel E.. Rheumatology, Albany Medical College, Albany, NY, USA; Rheumatology, UCLA Medical Center, Los Angeles, CA,USA; Rheumatology, Hospital General de Mexico, Mexico City, Mexico; Rheumatology, Universidad Nacional Autónoma de México, Mexico City, Mexico; Rheumatology, Hôpital orthopédique, Lausanne, Switzerland; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA
    • Burgos-Vargas, Ruben. Rheumatology, Albany Medical College, Albany, NY, USA; Rheumatology, UCLA Medical Center, Los Angeles, CA,USA; Rheumatology, Hospital General de Mexico, Mexico City, Mexico; Rheumatology, Universidad Nacional Autónoma de México, Mexico City, Mexico; Rheumatology, Hôpital orthopédique, Lausanne, Switzerland; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA
    • Dudler, Jean. Rheumatology, Albany Medical College, Albany, NY, USA; Rheumatology, UCLA Medical Center, Los Angeles, CA,USA; Rheumatology, Hospital General de Mexico, Mexico City, Mexico; Rheumatology, Universidad Nacional Autónoma de México, Mexico City, Mexico; Rheumatology, Hôpital orthopédique, Lausanne, Switzerland; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA
    • Mela, Christopher M.. Rheumatology, Albany Medical College, Albany, NY, USA; Rheumatology, UCLA Medical Center, Los Angeles, CA,USA; Rheumatology, Hospital General de Mexico, Mexico City, Mexico; Rheumatology, Universidad Nacional Autónoma de México, Mexico City, Mexico; Rheumatology, Hôpital orthopédique, Lausanne, Switzerland; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA
    • Vernon, Emma. Rheumatology, Albany Medical College, Albany, NY, USA; Rheumatology, UCLA Medical Center, Los Angeles, CA,USA; Rheumatology, Hospital General de Mexico, Mexico City, Mexico; Rheumatology, Universidad Nacional Autónoma de México, Mexico City, Mexico; Rheumatology, Hôpital orthopédique, Lausanne, Switzerland; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA
    • Fleischmann, Roy M.. Rheumatology, Albany Medical College, Albany, NY, USA; Rheumatology, UCLA Medical Center, Los Angeles, CA,USA; Rheumatology, Hospital General de Mexico, Mexico City, Mexico; Rheumatology, Universidad Nacional Autónoma de México, Mexico City, Mexico; Rheumatology, Hôpital orthopédique, Lausanne, Switzerland; Rheumatology, Roche, Welwyn, United Kingdom; Rheumatology, Metroplex Clinical Research Center, Dallas, TX, USA
    • Wegner, Natalia. The Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom; School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA; Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Lugli, Helena. The Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom; School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA; Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Quirke, Anne-Marie. The Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom; School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA; Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Guo, Yonghua. The Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom; School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA; Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Potempa, Jan. The Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom; School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA; Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Venables, Patrick. The Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom; School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY, USA; Department of Microbiology, Jagiellonian University, Krakow, Poland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:304282
    Summary
    Background: In Japan, more than 20 rheumatoid arthritis (RA) patients died of interstitial pneumonia (IP) caused by leflunomide (LEF) were reported, but many of them were considered as the victims of opportunistic infection currently. In this paper, efficacy and safety of low-dose LEF classified by body weight (BW) were studied. Methods: Fifty-nine RA patients were started to administrate LEF from July 2007 to July 2009. Among them, 25 patients were excluded because of the combination with tacrolimus, and medication modification within 3 months before LEF. Remaining 34 RA patients administered 20 to 50 mg/week of LEF were followed up for 1 year and enrolled in this study. Dose of LEF was classified by BW (50 mg/week for over 50 kg, 40 mg/week for 40 to 50 kg and 20 to 30 mg/week for under 40 kg). The average age and RA duration of enrolled patients were 55.5 years old and 10.2 years. Prednisolone (PSL), methotrexate (MTX) and etanercept were used in 23, 28 and 2 patients, respectively. In case of insufficient response or adverse effect, dosage change or discontinuance of LEF were considered. Failure was defined as dosages up of PSL and MTX, or dosages down or discontinuance of LEF. Last observation carried forward method was used for the evaluation of failed patients at 1 year. Results: At 1 year after LEF start, good/ moderate/ no response assessed by the European League Against Rheumatism (EULAR) response criteria using Disease Activity Score, including a 28-joint count (DAS28)-C reactive protein (CRP) were showed in 14/ 10/ 10 patients, respectively. The dosage changes of LEF at 1 year were dosage up: 10, same dosage: 5, dosage down: 8 and discontinuance: 11 patients. The survival rate of patients in this study was 23.5% (24 patients failed) but actual LEF continuous rate was 67.6% (11 patients discontinued) at 1 year. The major reason of failure was liver dysfunction, and pneumocystis pneumonia was occurred in 1 patient resulted in full recovery. One patient died of sepsis caused by decubitus ulcer infection. DAS28-CRP score was decreased from 3.9 to 2.7 significantly. Although CRP was decreased from 1.50 to 0.93 mg/dl, it wasn't significant. Matrix metalloproteinase (MMP)-3 was decreased from 220.0 to 174.2 ng/ml significantly. Glutamate pyruvate transaminase (GPT) was increased from 19 to 35 U/l and number of leukocyte was decreased from 7832 to 6271 significantly. DAS28-CRP, CRP, and MMP-3 were improved significantly with MTX, although they weren't without MTX. Increase of GPT and leukopenia were seen significantly with MTX, although they weren't without MTX. Conclusions: It was reported that the risks of IP caused by LEF in Japanese RA patients were past IP history, loading dose administration and low BW. Addition of low-dose LEF is a potent safe alternative for the patients showing unsatisfactory response to current medicines, but need to pay attention for liver function and infection caused by leukopenia, especially with MTX. Disclosure statement: The authors have declared no conflicts of interest