Thymosin beta 4 gene silencing decreases stemness and invasiveness in glioblastoma
Wirsching, Hans-Georg ; Krishnan, Shanmugarajan ; Florea, Ana-Maria ; Frei, Karl ; Krayenbühl, Niklaus ; Hasenbach, Kathy ; Reifenberger, Guido ; Weller, Michael ; Tabatabai, Ghazaleh
In: Brain, 2014, vol. 137, no. 2, p. 433-448
Aggiungi alla tua lista- Summary
- Glioblastomas are incurable malignant primary brain tumours. Wirsching etal. investigate the effects of altered expression of thymosin beta 4 (TB4), a polypeptide implicated in neural development and wound healing, in glioma models. TB4 silencing inhibited migration and invasion of glioma cells invitro, and enhanced survival of glioma-bearing mice