Thymosin beta 4 gene silencing decreases stemness and invasiveness in glioblastoma

Wirsching, Hans-Georg ; Krishnan, Shanmugarajan ; Florea, Ana-Maria ; Frei, Karl ; Krayenbühl, Niklaus ; Hasenbach, Kathy ; Reifenberger, Guido ; Weller, Michael ; Tabatabai, Ghazaleh

In: Brain, 2014, vol. 137, no. 2, p. 433-448

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    Summary
    Glioblastomas are incurable malignant primary brain tumours. Wirsching etal. investigate the effects of altered expression of thymosin beta 4 (TB4), a polypeptide implicated in neural development and wound healing, in glioma models. TB4 silencing inhibited migration and invasion of glioma cells invitro, and enhanced survival of glioma-bearing mice