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Parvalbumin: calcium and magnesium buffering in the distal nephron

Olinger, Eric ; Schwaller, Beat ; Loffing, Johannes ; Gailly, Philippe ; Devuyst, Olivier

In: Nephrology Dialysis Transplantation, 2012, vol. 27, no. 11, p. 3988-3994

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    Titre
    • Parvalbumin: calcium and magnesium buffering in the distal nephron
    Auteur
    • Olinger, Eric. Division of Nephrology and Laboratory of Cell Physiology, UCL Medical School, Brussels, Belgium
    • Schwaller, Beat. Division of Nephrology and Laboratory of Cell Physiology, UCL Medical School, Brussels, Belgium
    • Loffing, Johannes. Division of Nephrology and Laboratory of Cell Physiology, UCL Medical School, Brussels, Belgium
    • Gailly, Philippe. Division of Nephrology and Laboratory of Cell Physiology, UCL Medical School, Brussels, Belgium
    • Devuyst, Olivier. E-mail: olivier.devuyst@uzh.ch
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Nephrology Dialysis Transplantation, 2012, vol. 27, no. 11, p. 3988-3994. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:304093
    Summary
    Parvalbumin (PV) is a classical member of the EF-hand protein superfamily that has been described as a Ca2+ buffer and Ca2+ transporter/shuttle protein and may also play an additional role in Mg2+ handling. PV is exclusively expressed in the early part of the distal convoluted tubule in the human and mouse kidneys. Recent studies in Pvalb knockout mice revealed a role of PV in the distal handling of electrolytes: the lack of PV was associated with a mild salt-losing phenotype with secondary aldosteronism, salt craving and stronger bones compared with controls. A link between the Ca2+-buffering capacity of PV and the expression of the thiazide-sensitive Na+-Cl− cotransporter was established, which could be relevant to the regulation of sodium transport in the distal nephron. Variants in the PVALB gene that encodes PV have been described, but their relevance to kidney function has not been established. PV is also considered a reliable marker of chromophobe carcinoma and oncocytoma, two neoplasms deriving from the distal nephron. The putative role of PV in tumour genesis remains to be investigated