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Failure to Detect Xenotropic Murine Leukemia Virus-Related Virus in Blood of Individuals at High Risk of Blood-Borne Viral Infections

Barnes, Eleanor ; Flanagan, Peter ; Brown, Anthony ; Robinson, Nicola ; Brown, Helen ; McClure, Myra ; Oxenius, Annette ; Collier, Jane ; Weber, Jonathan ; Günthard, Huldrych F. ; Hirschel, Bernard ; Fidler, Sarah ; Phillips, Rodney ; Frater, John

In: The Journal of Infectious Diseases, 2010, vol. 202, no. 10, p. 1482-1485

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    Titel
    • Failure to Detect Xenotropic Murine Leukemia Virus-Related Virus in Blood of Individuals at High Risk of Blood-Borne Viral Infections
    Autor
    • Barnes, Eleanor. Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford
    • Flanagan, Peter. Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford
    • Brown, Anthony. Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford
    • Robinson, Nicola. Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford
    • Brown, Helen. Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford
    • McClure, Myra. Division of Medicine, Wright Fleming Institute, Imperial College London, St. Mary's Hospital, London, United Kingdom
    • Oxenius, Annette. Institute of Microbiology, ETH Zurich
    • Collier, Jane. Department of Gastroenterology, John Radcliffe Hospital NHS Trust, Oxford
    • Weber, Jonathan. Division of Medicine, Wright Fleming Institute, Imperial College London, St. Mary's Hospital, London, United Kingdom
    • Günthard, Huldrych F.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Zurich, Zurich
    • Hirschel, Bernard. Division of Infectious Diseases, University Hospital, CH-1211 Geneva, Switzerland
    • Fidler, Sarah. Division of Medicine, Wright Fleming Institute, Imperial College London, St. Mary's Hospital, London, United Kingdom
    • Phillips, Rodney. Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford
    • Frater, John. Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • The Journal of Infectious Diseases, 2010, vol. 202, no. 10, p. 1482-1485. The University of Chicago Press
    Andere elektronische Ausgabe
    Klassifikation
    • Gesundheit
    OAI-PMH-ID
    • oai:doc.rero.ch:303974
    Summary
    A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections fromthe United Kingdom and Western Europe