Failure to Detect Xenotropic Murine Leukemia Virus-Related Virus in Blood of Individuals at High Risk of Blood-Borne Viral Infections

Barnes, Eleanor ; Flanagan, Peter ; Brown, Anthony ; Robinson, Nicola ; Brown, Helen ; McClure, Myra ; Oxenius, Annette ; Collier, Jane ; Weber, Jonathan ; Günthard, Huldrych F. ; Hirschel, Bernard ; Fidler, Sarah ; Phillips, Rodney ; Frater, John

In: The Journal of Infectious Diseases, 2010, vol. 202, no. 10, p. 1482-1485

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    A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections fromthe United Kingdom and Western Europe