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Hypertension does not Affect Intracellular Calcium uptake in Human Platelets

Eberhard, Marc ; Evéquoz, Dominique ; Erne, Paul

In: American Journal of Hypertension, 1996, vol. 9, no. 2, p. 137-143

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    Titre
    • Hypertension does not Affect Intracellular Calcium uptake in Human Platelets
    Auteur
    • Eberhard, Marc. Department of Research, Kantonsspital, Basel, Switzerland
    • Evéquoz, Dominique. Division of Cardiology, Kantonsspital, Luzern, Switzerland
    • Erne, Paul. Division of Cardiology, Kantonsspital, Luzern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • American Journal of Hypertension, 1996, vol. 9, no. 2, p. 137-143. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302935
    Summary
    The relationship between the Ca2+ transport of platelet endoplasmic reticulum and hypertension was analyzed in 17 untreated patients exhibiting various degrees of hypertension. Each patient underwent a 24-h recording of ambulatory blood pressure. Platelets from patients were permeabilized with saponin and the rate of ATP-driven thapsigargin-sensitive Ca2+ uptake determined using the fluorescent Ca2+ indicator fluo-3. No relationship between blood pressure (systolic, diastolic, day, night) and the rate of Ca2+ uptake into the sacroplasmic reticulum of platelets was found. A weak but insignificant correlation between Ca2+ uptake and the heart rate was noted. Therefore, the increase in cytosolic Ca2+ of platelets in hypertension may not be due to changes of the activity of Ca2+ uptake into the sacroplasmic reticulum. Am J Hypertens 1996;9:136-142