Fulltext

Relative concentrations of haemostatic factors and cytokines in solvent/detergent-treated and fresh-frozen plasma

Theusinger, O. M. ; Baulig, W. ; Seifert, B. ; Emmert, M. Y. ; Spahn, D. R. ; Asmis, L. M.

In: British Journal of Anaesthesia, 2011, vol. 106, no. 4, p. 505-511

Ajouter à la liste personnelle
    Titre
    • Relative concentrations of haemostatic factors and cytokines in solvent/detergent-treated and fresh-frozen plasma
    Auteur
    • Theusinger, O. M.. Institute of Anaesthesiology
    • Baulig, W.. Institute of Anaesthesiology
    • Seifert, B.. Biostatistics Unit, Institute of Social and Preventive Medicine, University of Zurich, Switzerland
    • Emmert, M. Y.. Clinic of Cardiac and Vascular Surgery, University Hospital Zurich, Zurich, Switzerland
    • Spahn, D. R.. Institute of Anaesthesiology
    • Asmis, L. M.. Division of Haematology and
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • British Journal of Anaesthesia, 2011, vol. 106, no. 4, p. 505-511. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302733
    Summary
    Background Indications, efficacy, and safety of plasma products are highly debated. We compared the concentrations of haemostatic proteins and cytokines in solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP). Methods Concentrations of the following parameters were measured in 25 SDP and FFP samples: fibrinogen (FBG), factor (F) II, F V, F VII, F VIII, F IX, F X, F XIII, von Willebrand factor (vWF), D-Dimers, ADAMTS-13 protease, tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, and IL-10. Results Mean FBG concentrations in SDP and FFP were similar, but in FFP, the range was larger than in SDP (P<0.01). Mean F II, F VII, F VIII, F IX, and F XIII levels did not differ significantly. Higher concentrations of F V (P<0.01), F X (P<0.05), vWF (P<0.01), and ADAMTS-13 (P<0.01) were found in FFP. With the exception of F VIII and F IX, the range of concentrations for all of these factors was smaller (P<0.05) in SDP than in FFP. Concentrations of TNF-α, IL-8, and IL-10 (all P<0.01) were higher in FFP than in SDP, again with a higher variability and thus larger ranges (P<0.01). Conclusions Coagulation factor content is similar for SDP and FFP, with notable exceptions of less F V, vWF, and ADAMTS-13 in SDP. Cytokine concentrations (TNFα, IL-8, and IL-10) were significantly higher in FFP. The clinical relevance of these findings needs to be established in outcome studies