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Absence of Chronic Human Immunodeficiency Virus Infection without Seroconversion in Intravenous Drug Users: A Prospective and Retrospective Study

Yerly, Sabine ; Chamot, Eric ; Deglon, Jean-Jacques ; Hirschel, Bernard ; Perrin, Luc Henri

In: Journal of Infectious Diseases, 1991, vol. 164, no. 5, p. 965-968

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    Titre
    • Absence of Chronic Human Immunodeficiency Virus Infection without Seroconversion in Intravenous Drug Users: A Prospective and Retrospective Study
    Auteur
    • Yerly, Sabine. Central Laboratory of Virology, Division of Infectious Disease, and Medical Outpatient Clinic, Geneva University Hospital, and Ermitage Therapeutic Center, Geneva, Switzerland
    • Chamot, Eric. Central Laboratory of Virology, Division of Infectious Disease, and Medical Outpatient Clinic, Geneva University Hospital, and Ermitage Therapeutic Center, Geneva, Switzerland
    • Deglon, Jean-Jacques. Central Laboratory of Virology, Division of Infectious Disease, and Medical Outpatient Clinic, Geneva University Hospital, and Ermitage Therapeutic Center, Geneva, Switzerland
    • Hirschel, Bernard. Central Laboratory of Virology, Division of Infectious Disease, and Medical Outpatient Clinic, Geneva University Hospital, and Ermitage Therapeutic Center, Geneva, Switzerland
    • Perrin, Luc Henri. Central Laboratory of Virology, Division of Infectious Disease, and Medical Outpatient Clinic, Geneva University Hospital, and Ermitage Therapeutic Center, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Infectious Diseases, 1991, vol. 164, no. 5, p. 965-968. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302624
    Summary
    It has been reported that human immunodeficiency virus type 1 (HIV-1) infection may exist in persons without specific antibodies for years. To measure the frequency of a silent carrier state, a study was conducted in a cohort of 124 intravenous drug users (IVDUs) without anti-HIV-1 antibodies. All the participants had engaged in high-risk behavior for HIV-1 transmission for a number of years until 1987 or later. Samples were analyzed at 6-month intervals for the presence of HIV-1 provirus using DNA amplification and for the appearance of anti-HIV-1 antibodies. HIV-1 provirus and antibodies were undetectable in 122 participants, whereas seroconversion was observed in 2. In one of these, both amplified HIV-1 pol gene segment and anti-HIV-1 antibodies were detected simultaneously, and in the other, provirus was detected 1 month before seroconversion. This study suggests that long-term HIV-1 infection without anti-HIV-1 antibodies is rare and that repeated antibody testing is sufficient to determine the HIV-1 status of a person no longer at high risk for HIV-1 infection