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Codon 215 Mutations in Human Immunodeficiency Virus—Infected Pregnant Women

Kully, Charlotte ; Yerly, Sabine ; Erb, Peter ; Kind, Christian ; Krautheim, Alexandra ; Perrin, Luc ; Rudin, Christoph

In: The Journal of Infectious Diseases, 1999, vol. 179, no. 3, p. 705-708

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    Titre
    • Codon 215 Mutations in Human Immunodeficiency Virus—Infected Pregnant Women
    Auteur
    • Kully, Charlotte. University Children's Hospital and Institute of Medical Microbiology, University of Basel, Basel; Laboratory of Virology, Division of Infectious Diseases, University Hospital, Geneva; Division of Neonatology, Kantonsspital, St. Gallen, Switzerland
    • Yerly, Sabine. University Children's Hospital and Institute of Medical Microbiology, University of Basel, Basel; Laboratory of Virology, Division of Infectious Diseases, University Hospital, Geneva; Division of Neonatology, Kantonsspital, St. Gallen, Switzerland
    • Erb, Peter. University Children's Hospital and Institute of Medical Microbiology, University of Basel, Basel; Laboratory of Virology, Division of Infectious Diseases, University Hospital, Geneva; Division of Neonatology, Kantonsspital, St. Gallen, Switzerland
    • Kind, Christian. University Children's Hospital and Institute of Medical Microbiology, University of Basel, Basel; Laboratory of Virology, Division of Infectious Diseases, University Hospital, Geneva; Division of Neonatology, Kantonsspital, St. Gallen, Switzerland
    • Krautheim, Alexandra. University Children's Hospital and Institute of Medical Microbiology, University of Basel, Basel; Laboratory of Virology, Division of Infectious Diseases, University Hospital, Geneva; Division of Neonatology, Kantonsspital, St. Gallen, Switzerland
    • Perrin, Luc. University Children's Hospital and Institute of Medical Microbiology, University of Basel, Basel; Laboratory of Virology, Division of Infectious Diseases, University Hospital, Geneva; Division of Neonatology, Kantonsspital, St. Gallen, Switzerland
    • Rudin, Christoph. University Children's Hospital and Institute of Medical Microbiology, University of Basel, Basel; Laboratory of Virology, Division of Infectious Diseases, University Hospital, Geneva; Division of Neonatology, Kantonsspital, St. Gallen, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The Journal of Infectious Diseases, 1999, vol. 179, no. 3, p. 705-708. The University Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302420
    Summary
    In 1994, the Pediatric AIDS Clinical Trials Group (PACTG) Protocol 076 demonstrated a two-thirds reduction of perinatal human immunodeficiency virus (HIV) type 1 transmission with zidovudine chemoprophylaxis. However, zidovudine alone does not fully suppress HIV replication, and chemoprophylaxis with zidovudine alone might select for zidovudine-resistant viral variants, decreasing the efficacy of zidovudine prophylaxis and affecting future responses to combined antiretroviral regimens. Sixty-two HIV-infected pregnant women consecutively enrolled in the ongoing Swiss HIV and Pregnancy Study were prospectively evaluated for the presence or development of zidovudine resistance by analysis of codon 215 of the reverse transcriptase gene. Six women (9.6%) harbored a codon T215Y/F mutation, which is associated with high-level resistance to zidovudine. Postnatal evaluation was completed in all children of mothers harboring the mutation. None was HIV-infected. The observed prevalence of codon 215 mutations of 9.6% raises important concerns regarding the future use of the PACTG 076 regimen