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Adjuvant Chemotherapy With Sequential or Concurrent Anthracycline and Docetaxel: Breast International Group 02-98 Randomized Trial
Francis, Prudence ; Crown, John ; Di Leo, Angelo ; Buyse, Marc ; Balil, Ana ; Andersson, Michael ; Nordenskjöld, Bo ; Lang, Istvan ; Jakesz, Raimund ; Vorobiof, Daniel ; Gutiérrez, Jorge ; van Hazel, Guy ; Dolci, Stella ; Jamin, Sophie ; Bendahmane, Belguendouz ; Gelber, Richard D. ; Goldhirsch, Aron ; Castiglione-Gertsch, Monica ; Piccart-Gebhart, Martine
In: Journal of the National Cancer Institute, 2008, vol. 100, no. 2, p. 121-133
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- Adjuvant Chemotherapy With Sequential or Concurrent Anthracycline and Docetaxel: Breast International Group 02-98 Randomized Trial
- Auteur
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- Francis, Prudence. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Crown, John. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Di Leo, Angelo. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Buyse, Marc. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Balil, Ana. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Andersson, Michael. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Nordenskjöld, Bo. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Lang, Istvan. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Jakesz, Raimund. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Vorobiof, Daniel. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Gutiérrez, Jorge. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- van Hazel, Guy. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Dolci, Stella. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Jamin, Sophie. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Bendahmane, Belguendouz. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Gelber, Richard D.. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Goldhirsch, Aron. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Castiglione-Gertsch, Monica. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Piccart-Gebhart, Martine. Affiliations of authors: Peter MacCallum Cancer Centre, Melbourne, Australia (PF); Australian New Zealand Breast Cancer Trials Group, Newcastle, Australia (PF); International Breast Cancer Study Group, Bern, Switzerland (PF); Irish Clinical Oncology Research Group, Dublin, Ireland (JC); Hospital of Prato, Prato, Italy (ADL); International Drug Development Institute, Louvain-la-Neuve, Belgium (MB); Grupo Español de Investigacion en Cancer de Mama, Madrid, Spain (AB); Hospital Arnau de Vilanova, Lleida, Spain (AB); Danish Breast Cancer Cooperative Group, Copenhagen, Denmark (MA); Swedish Breast Cancer Group, Universitetssjukhuset, Linkoping, Sweden (BN); National Institute of Oncology, Budapest, Hungary (IL); Austrian Breast and Colorectal Cancer Study Group, Vienna Medical School, Vienna, Austria (RJ); Sandton Oncology Centre, Johannesburg, South Africa (DV); Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile (JG); Mount Hospital, Perth, Australia (GvH); Breast European Adjuvant Studies Team, Jules Bordet Institute, Brussels, Belgium (SD, SJ, MPG); sanofi-aventis, Paris, France (BB); International Breast Cancer Study Group (IBCSG), Statistical Centre and Dana Farber Cancer Institute, Boston, MA (RDG); IBCSG Scientific Committee, European Institute of Oncology, Milan, Italy (AG); IBCSG Coordinating Centre and Inselspital, Bern, Switzerland (MCG)
- Type de document
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- Postprint
- Langue
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- Anglais
- Publié dans
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- Journal of the National Cancer Institute, 2008, vol. 100, no. 2, p. 121-133. Oxford University Press
- Autre version électronique
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- Publisher's version : https://doi.org/10.1093/jnci/djm287
- Classification
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- Santé
- Mots clés
- Identifiant OAI-PMH
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- oai:doc.rero.ch:302356
- Summary
- Background Docetaxel is more effective than doxorubicin for patients with advanced breast cancer. The Breast International Group 02-98 randomized trial tested the effect of incorporating docetaxel into anthracycline-based adjuvant chemotherapy and compared sequential vs concurrent administration of doxorubicin and docetaxel. Methods Patients with lymph node-positive breast cancer (n = 2887) were randomly assigned to one of four treatments: 1) sequential control (four cycles of doxorubicin at 75 mg/m2, followed by three cycles of cyclophosphamide, methotrexate, and 5-fluorouracil [CMF]); 2) concurrent control (four cycles of doxorubicin at 60 mg/m2 plus cyclophosphamide at 600 mg/m2, followed by three cycles of CMF); 3) sequential docetaxel (three cycles of doxorubicin at 75 mg/m2, followed by three cycles of docetaxel at 100 mg/m2, followed by three cycles of CMF); 4) concurrent docetaxel (four cycles of doxorubicin at 50 mg/m2 plus docetaxel at 75 mg/m2, followed by three cycles of CMF). The primary comparison evaluated the efficacy of including docetaxel regardless of schedule and was planned after 1215 disease-free survival (DFS) events (ie, relapse, second primary cancer, or death from any cause). Docetaxel and control treatment groups were compared by log-rank tests, and hazard ratios (HR) of DFS events were calculated by Cox modeling. All statistical tests were two-sided. Results Due to a lower-than-anticipated rate of relapse, this analysis was performed after 5 years with 732 events. Patients in control arms had a 5-year DFS of 73% (95% confidence interval [CI] = 70% to 75%). Docetaxel treatment resulted in an improvement in DFS of borderline statistical significance compared with control treatment (HR = 0.86, 95% CI = 0.74 to 1.00; P = .05). However, DFS in the sequential docetaxel arm was better than that in the concurrent docetaxel arm (HR = 0.83, 95% CI = 0.69 to 1.00) and in the sequential control arm (HR = 0.79, 95% CI = 0.64 to 0.98). Conclusions Incorporating docetaxel into anthracycline-based therapy resulted in an improvement in DFS that was of borderline statistical significance. However, important differences may be related to doxorubicin and docetaxel scheduling, with sequential but not concurrent administration, appearing to produce better DFS than anthracycline-based chemotherapy