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Maize and Risk of Cancers of the Oral Cavity, Pharynx, and Esophagus in Northeastern Italy

Franceschi, Silvia ; Bidoli, Ettore ; Barón, Anna E. ; La Vecchia, Carlo

In: JNCI: Journal of the National Cancer Institute, 1990, vol. 82, no. 17, p. 1407-1411

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    Titre
    • Maize and Risk of Cancers of the Oral Cavity, Pharynx, and Esophagus in Northeastern Italy
    Auteur
    • Franceschi, Silvia. Epidemiology Unit, Aviano Cancer Center Aviano (PN), Italy
    • Bidoli, Ettore. Epidemiology Unit, Aviano Cancer Center Aviano (PN), Italy
    • Barón, Anna E.. Epidemiology Unit, Aviano Cancer Center Aviano (PN), Italy
    • La Vecchia, Carlo. "Mario Negri” Institute for Pharmacological Research Milan, Italy Institute of Social and Preventive Medicine, University of Lausanne Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • JNCI: Journal of the National Cancer Institute, 1990, vol. 82, no. 17, p. 1407-1411. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Mots clés
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302255
    Summary
    The relationship between maize consumption and risk of cancer of the upper digestive tract was investigated in 107 patients with oral cancer, 107 with pharyngeal cancer, 68 with esophageal cancer, and 505 hospital controls who permanently resided in Pordenone Province in the northeastern part of Italy. The analysis was restricted to males. The population of this province has a high incidence of these neoplasms and shows particularly elevated levels of alcohol and tobacco use, in addition to high maize consumption. Highly significant associations with frequent intake of maize emerged for oral cancer, pharyngeal cancer, and esophageal cancer (odds ratios = 3.3, 3.2, and 2.8, respectively). The risk elevation could not be explained in terms of differences in education, occupation, tobacco use, or consumption of fresh fruits and vegetables. The unfavorable effect of maize on risk of cancer of the upper digestive tract, however, was evident only in those individuals who reported heavy drinking (i.e., ≥42 alcoholic drinks/wk). The present findings are likely to be related to the fact that maize can cause deficiencies of various micronutrients (chiefly, niacin and riboflavin) and agree with previous observations from Africa, the People's Republic of China, the United States, and Italy. [J Natl Cancer Inst 82:1407-1411, 1990]