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Monographs on drugs which are frequently analyzed in therapeutic drug monitoring

Rentsch, Working group "Drug Monitoring” of the SSCC: Katharina ; Buhl, Daniela ; Eap, Chin Bin ; Fathi, Marc ; Jöchle, Wolfgang ; Magnin, Jean-Luc ; Thormann, Wolfgang ; Werner, Dominique

In: LaboratoriumsMedizin, 2010, vol. 34, no. 3, p. 129-139

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    Titre
    • Monographs on drugs which are frequently analyzed in therapeutic drug monitoring
    Auteur
    • Rentsch, Working group "Drug Monitoring” of the SSCC: Katharina. University Hospital Zurich, Zurich, Switzerland
    • Buhl, Daniela. University Hospital Bern, Bern, Switzerland
    • Eap, Chin Bin. University Hospital Lausanne, Lausanne, Switzerland
    • Fathi, Marc. University Hospital Geneva, Geneva, Switzerland
    • Jöchle, Wolfgang. University Hospital Basel, Basel, Switzerland
    • Magnin, Jean-Luc. Kantonsspital Freiburg, Freiburg, Switzerland
    • Thormann, Wolfgang. University of Bern, Bern, Switzerland
    • Werner, Dominique. University Hospital Lausanne, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Multilingue
    Publié dans
    • LaboratoriumsMedizin, 2010, vol. 34, no. 3, p. 129-139. Walter de Gruyter
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301916
    Summary
    In addition to the monographs which have been published in the past 4 years by the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) [1-4], new monographs have been written. The data presented in these monographs provide an overview of important information for the request and interpretation of results. Therefore, laboratory health professionals and the receivers of the reports are the targeted readers. In this series, several antiepileptic drugs are presented. Monographs on carbamazepine [1], lamotrigine [2], phenobarbital [2], and valproic acid [2] have been published previously. First, information about pharmacology and pharmacokinetics of these drugs (protein binding, metabolic pathways and enzymes involved, elimination half-life time and elimination route(s) of the parent drug and therapeutic as well as toxic concentrations) is given. Second, the indications for therapeutic drug monitoring are listed. Last but not least, important pre-analytical information is provided, including time points of blood sampling and time interval after which steady-state concentrations are reached after changing the dose. Furthermore, the stability of the drug and its metabolite(s) after blood sampling is described. For readers with a specific interest, references to important publications are given. The number of the monographs will be further enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful for the better handling of therapeutic drug monitoring and we are looking forward to comments from the readers