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The Sulfinator: predicting tyrosine sulfation sites inprotein sequences

Monigatti, Flavio ; Gasteiger, Elisabeth ; Bairoch, Amos ; Jung, Eva

In: Bioinformatics, 2002, vol. 18, no. 5, p. 769-770

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    Titre
    • The Sulfinator: predicting tyrosine sulfation sites inprotein sequences
    Auteur
    • Monigatti, Flavio. SWISS-PROT Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
    • Gasteiger, Elisabeth. SWISS-PROT Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
    • Bairoch, Amos. SWISS-PROT Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
    • Jung, Eva. SWISS-PROT Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
    Type de document
    • Postprint
    Classification
    • Informatique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301808
    Summary
    Summary: Protein tyrosine sulfation is an important post-translational modification of proteins that go through the secretory pathway. No clear-cut acceptor motif can be defined that allows the prediction of tyrosine sulfation sites in polypeptide chains. The Sulfinator is a software tool that can be used to predict tyrosine sulfation sites in protein sequences with an overall accuracy of 98%. Four different Hidden Markov Models were constructed, each of them specialized to recognize sulfated tyrosine residues depending on their location within the sequence: near the N-terminus, near the C-terminus, in the center of a window with a size of at least 25 amino acids, as well as in windows containing several tyrosine residues. Availability: The Sulfinator is accessible at (http://www.expasy.org/tools/sulfinator/). Supplementary information: Sulfinator documentation is accessible at (http://www.expasy.org/tools/sulfinator/sulfinator-doc.html). Abbreviations: SWP: SWISS-PROT accession number. * To whom correspondence should be addressed