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Novel pathways of antigen presentation for the maintenance of memory

Gray, David ; Kosco, Marie ; Stockinger, Brigitta

In: International Immunology, 1991, vol. 3, no. 2, p. 141-148

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    Titre
    • Novel pathways of antigen presentation for the maintenance of memory
    Auteur
    • Gray, David. Basel Institute for Immunology, Grenzacherstrasse 487, Postfach CH 4005, Basel, Switzerland
    • Kosco, Marie. Basel Institute for Immunology, Grenzacherstrasse 487, Postfach CH 4005, Basel, Switzerland
    • Stockinger, Brigitta. Basel Institute for Immunology, Grenzacherstrasse 487, Postfach CH 4005, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • International Immunology, 1991, vol. 3, no. 2, p. 141-148. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301784
    Summary
    Follicular dendritic cells (FDC) store native antigen for long periods In tymphoid follicles and so provide a source ofcontinued stimulation for specific B cells. The expression of MHC class II by FDC suggested they might act as antigen-presenting cells for MHC class ll-restricted T cells. We show here, however, that the MHC class II molecules found on their surface are not synthesized by the FDC but are picked up from surrounding B cells In germinal centres. Although FDC by themselves cannot present native antigen to T cells, acquired MHC class ll-peptlde complexes can be recognized by T cells. The true physiological role of FDC seems to be as long-term antigen depots. We demonstrate that antigen localized onto FDC In vivo can be retrieved by antigen-specific B cells, which In turn process and present It to T cells. Thesepresentation pathways are likely to be crucial In both the maintenance of long-term Immune responses and the continued survival of memory cells